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Humoral response in Leishmaniasis

Leishmaniasis presents different types of clinical manifestations that can be divided into cutaneous leishmaniasis and visceral leishmaniasis. The host’s immune system, associated with genetic and nutritional factors, is strongly involved in the evolution of the disease or parasite escape. Humoral i...

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Autores principales: Conde, Luciana, Maciel, Gabriela, de Assis, Gustavo Meira, Freire-de-Lima, Leonardo, Nico, Dirlei, Vale, André, Freire-de-Lima, Célio Geraldo, Morrot, Alexandre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791258/
https://www.ncbi.nlm.nih.gov/pubmed/36579347
http://dx.doi.org/10.3389/fcimb.2022.1063291
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author Conde, Luciana
Maciel, Gabriela
de Assis, Gustavo Meira
Freire-de-Lima, Leonardo
Nico, Dirlei
Vale, André
Freire-de-Lima, Célio Geraldo
Morrot, Alexandre
author_facet Conde, Luciana
Maciel, Gabriela
de Assis, Gustavo Meira
Freire-de-Lima, Leonardo
Nico, Dirlei
Vale, André
Freire-de-Lima, Célio Geraldo
Morrot, Alexandre
author_sort Conde, Luciana
collection PubMed
description Leishmaniasis presents different types of clinical manifestations that can be divided into cutaneous leishmaniasis and visceral leishmaniasis. The host’s immune system, associated with genetic and nutritional factors, is strongly involved in the evolution of the disease or parasite escape. Humoral immunity is characterized by the production of antibodies capable of promoting neutralization, opsonization, and activation of the complement system. In this scenario, B lymphocytes produce antibodies that play an important role in Leishmania infection although neglected for a long time. Thus, relevant aspects in the establishment of Leishmania infection will be addressed, highlighting the importance of humoral immunity during the entire process of Leishmania infection.
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spelling pubmed-97912582022-12-27 Humoral response in Leishmaniasis Conde, Luciana Maciel, Gabriela de Assis, Gustavo Meira Freire-de-Lima, Leonardo Nico, Dirlei Vale, André Freire-de-Lima, Célio Geraldo Morrot, Alexandre Front Cell Infect Microbiol Cellular and Infection Microbiology Leishmaniasis presents different types of clinical manifestations that can be divided into cutaneous leishmaniasis and visceral leishmaniasis. The host’s immune system, associated with genetic and nutritional factors, is strongly involved in the evolution of the disease or parasite escape. Humoral immunity is characterized by the production of antibodies capable of promoting neutralization, opsonization, and activation of the complement system. In this scenario, B lymphocytes produce antibodies that play an important role in Leishmania infection although neglected for a long time. Thus, relevant aspects in the establishment of Leishmania infection will be addressed, highlighting the importance of humoral immunity during the entire process of Leishmania infection. Frontiers Media S.A. 2022-12-12 /pmc/articles/PMC9791258/ /pubmed/36579347 http://dx.doi.org/10.3389/fcimb.2022.1063291 Text en Copyright © 2022 Conde, Maciel, de Assis, Freire-de-Lima, Nico, Vale, Freire-de-Lima and Morrot https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Conde, Luciana
Maciel, Gabriela
de Assis, Gustavo Meira
Freire-de-Lima, Leonardo
Nico, Dirlei
Vale, André
Freire-de-Lima, Célio Geraldo
Morrot, Alexandre
Humoral response in Leishmaniasis
title Humoral response in Leishmaniasis
title_full Humoral response in Leishmaniasis
title_fullStr Humoral response in Leishmaniasis
title_full_unstemmed Humoral response in Leishmaniasis
title_short Humoral response in Leishmaniasis
title_sort humoral response in leishmaniasis
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791258/
https://www.ncbi.nlm.nih.gov/pubmed/36579347
http://dx.doi.org/10.3389/fcimb.2022.1063291
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