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Humoral response in Leishmaniasis
Leishmaniasis presents different types of clinical manifestations that can be divided into cutaneous leishmaniasis and visceral leishmaniasis. The host’s immune system, associated with genetic and nutritional factors, is strongly involved in the evolution of the disease or parasite escape. Humoral i...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791258/ https://www.ncbi.nlm.nih.gov/pubmed/36579347 http://dx.doi.org/10.3389/fcimb.2022.1063291 |
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author | Conde, Luciana Maciel, Gabriela de Assis, Gustavo Meira Freire-de-Lima, Leonardo Nico, Dirlei Vale, André Freire-de-Lima, Célio Geraldo Morrot, Alexandre |
author_facet | Conde, Luciana Maciel, Gabriela de Assis, Gustavo Meira Freire-de-Lima, Leonardo Nico, Dirlei Vale, André Freire-de-Lima, Célio Geraldo Morrot, Alexandre |
author_sort | Conde, Luciana |
collection | PubMed |
description | Leishmaniasis presents different types of clinical manifestations that can be divided into cutaneous leishmaniasis and visceral leishmaniasis. The host’s immune system, associated with genetic and nutritional factors, is strongly involved in the evolution of the disease or parasite escape. Humoral immunity is characterized by the production of antibodies capable of promoting neutralization, opsonization, and activation of the complement system. In this scenario, B lymphocytes produce antibodies that play an important role in Leishmania infection although neglected for a long time. Thus, relevant aspects in the establishment of Leishmania infection will be addressed, highlighting the importance of humoral immunity during the entire process of Leishmania infection. |
format | Online Article Text |
id | pubmed-9791258 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97912582022-12-27 Humoral response in Leishmaniasis Conde, Luciana Maciel, Gabriela de Assis, Gustavo Meira Freire-de-Lima, Leonardo Nico, Dirlei Vale, André Freire-de-Lima, Célio Geraldo Morrot, Alexandre Front Cell Infect Microbiol Cellular and Infection Microbiology Leishmaniasis presents different types of clinical manifestations that can be divided into cutaneous leishmaniasis and visceral leishmaniasis. The host’s immune system, associated with genetic and nutritional factors, is strongly involved in the evolution of the disease or parasite escape. Humoral immunity is characterized by the production of antibodies capable of promoting neutralization, opsonization, and activation of the complement system. In this scenario, B lymphocytes produce antibodies that play an important role in Leishmania infection although neglected for a long time. Thus, relevant aspects in the establishment of Leishmania infection will be addressed, highlighting the importance of humoral immunity during the entire process of Leishmania infection. Frontiers Media S.A. 2022-12-12 /pmc/articles/PMC9791258/ /pubmed/36579347 http://dx.doi.org/10.3389/fcimb.2022.1063291 Text en Copyright © 2022 Conde, Maciel, de Assis, Freire-de-Lima, Nico, Vale, Freire-de-Lima and Morrot https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cellular and Infection Microbiology Conde, Luciana Maciel, Gabriela de Assis, Gustavo Meira Freire-de-Lima, Leonardo Nico, Dirlei Vale, André Freire-de-Lima, Célio Geraldo Morrot, Alexandre Humoral response in Leishmaniasis |
title | Humoral response in Leishmaniasis |
title_full | Humoral response in Leishmaniasis |
title_fullStr | Humoral response in Leishmaniasis |
title_full_unstemmed | Humoral response in Leishmaniasis |
title_short | Humoral response in Leishmaniasis |
title_sort | humoral response in leishmaniasis |
topic | Cellular and Infection Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791258/ https://www.ncbi.nlm.nih.gov/pubmed/36579347 http://dx.doi.org/10.3389/fcimb.2022.1063291 |
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