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Air pollution exposure and pregnancy outcomes among women with polycystic ovary syndrome
BACKGROUND: Recently, the relationship between air pollution and reproductive outcomes has become a research focus. However, there is a lack of research on the relationship between air pollution and polycystic ovary syndrome (PCOS). METHODS: This is a retrospective cohort study included a total of 1...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791261/ https://www.ncbi.nlm.nih.gov/pubmed/36579067 http://dx.doi.org/10.3389/fpubh.2022.1066899 |
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author | Zhu, Qianqian Cai, Jing Guo, Haiyan Zhao, Yan Lin, Jiaying |
author_facet | Zhu, Qianqian Cai, Jing Guo, Haiyan Zhao, Yan Lin, Jiaying |
author_sort | Zhu, Qianqian |
collection | PubMed |
description | BACKGROUND: Recently, the relationship between air pollution and reproductive outcomes has become a research focus. However, there is a lack of research on the relationship between air pollution and polycystic ovary syndrome (PCOS). METHODS: This is a retrospective cohort study included a total of 1,652 women with PCOS and 12,543 women without PCOS conducted from 1 January 2015 to 31 December 2019. The average daily concentration data of six air pollutants (PM(2.5), PM(10), O(3), NO(2), SO(2), and CO) during different exposure windows were obtained. Generalized estimating equation models were used to evaluate the association of air pollution with pregnancy outcomes. RESULTS: Air pollutants were not found to have a significant association with pregnancy rates among patients with PCOS. However, each IQR increase in PM(10) exposure during period 3 (embryo transfer to serum HCG test) was associated with the reduced clinical pregnancy rate (adjusted OR = 0.92, 95% CI: 0.84–0.99) for patients without PCOS. Patients without PCOS showed lower clinical pregnancy rates with increased exposure to NO(2) during periods 2 (oocyte retrieval to embryo transfer) and 5 (start of gonadotropin medication to embryo transfer), with aORs and 95% CIs of 0.94 (0.88, 0.99) and 0.94 (0.88, 0.98), respectively. Each IQR increase in SO(2) among patients without PCOS during periods 1 (start of gonadotropin medication to oocyte retrieval), 2, 5, and 6 (start of gonadotropin medication to serum HCG test) was related to a decrease in clinical pregnancy rate. For the live birth rate, no significant relationship was found between air pollutants, including PM(2.5), PM(10), SO(2), NO(2), CO, and O(3), and the live birth rate for women with PCOS. However, women without PCOS presented a lower probability of live birth with exposure to SO(2) during periods 1, 2, 5, and 6. CONCLUSION: This retrospective study of reproductive-aged women observed no significant relationships between ambient pollutants and pregnancy outcomes among women with PCOS but found negative associations among women without PCOS. |
format | Online Article Text |
id | pubmed-9791261 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97912612022-12-27 Air pollution exposure and pregnancy outcomes among women with polycystic ovary syndrome Zhu, Qianqian Cai, Jing Guo, Haiyan Zhao, Yan Lin, Jiaying Front Public Health Public Health BACKGROUND: Recently, the relationship between air pollution and reproductive outcomes has become a research focus. However, there is a lack of research on the relationship between air pollution and polycystic ovary syndrome (PCOS). METHODS: This is a retrospective cohort study included a total of 1,652 women with PCOS and 12,543 women without PCOS conducted from 1 January 2015 to 31 December 2019. The average daily concentration data of six air pollutants (PM(2.5), PM(10), O(3), NO(2), SO(2), and CO) during different exposure windows were obtained. Generalized estimating equation models were used to evaluate the association of air pollution with pregnancy outcomes. RESULTS: Air pollutants were not found to have a significant association with pregnancy rates among patients with PCOS. However, each IQR increase in PM(10) exposure during period 3 (embryo transfer to serum HCG test) was associated with the reduced clinical pregnancy rate (adjusted OR = 0.92, 95% CI: 0.84–0.99) for patients without PCOS. Patients without PCOS showed lower clinical pregnancy rates with increased exposure to NO(2) during periods 2 (oocyte retrieval to embryo transfer) and 5 (start of gonadotropin medication to embryo transfer), with aORs and 95% CIs of 0.94 (0.88, 0.99) and 0.94 (0.88, 0.98), respectively. Each IQR increase in SO(2) among patients without PCOS during periods 1 (start of gonadotropin medication to oocyte retrieval), 2, 5, and 6 (start of gonadotropin medication to serum HCG test) was related to a decrease in clinical pregnancy rate. For the live birth rate, no significant relationship was found between air pollutants, including PM(2.5), PM(10), SO(2), NO(2), CO, and O(3), and the live birth rate for women with PCOS. However, women without PCOS presented a lower probability of live birth with exposure to SO(2) during periods 1, 2, 5, and 6. CONCLUSION: This retrospective study of reproductive-aged women observed no significant relationships between ambient pollutants and pregnancy outcomes among women with PCOS but found negative associations among women without PCOS. Frontiers Media S.A. 2022-12-12 /pmc/articles/PMC9791261/ /pubmed/36579067 http://dx.doi.org/10.3389/fpubh.2022.1066899 Text en Copyright © 2022 Zhu, Cai, Guo, Zhao and Lin. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Public Health Zhu, Qianqian Cai, Jing Guo, Haiyan Zhao, Yan Lin, Jiaying Air pollution exposure and pregnancy outcomes among women with polycystic ovary syndrome |
title | Air pollution exposure and pregnancy outcomes among women with polycystic ovary syndrome |
title_full | Air pollution exposure and pregnancy outcomes among women with polycystic ovary syndrome |
title_fullStr | Air pollution exposure and pregnancy outcomes among women with polycystic ovary syndrome |
title_full_unstemmed | Air pollution exposure and pregnancy outcomes among women with polycystic ovary syndrome |
title_short | Air pollution exposure and pregnancy outcomes among women with polycystic ovary syndrome |
title_sort | air pollution exposure and pregnancy outcomes among women with polycystic ovary syndrome |
topic | Public Health |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791261/ https://www.ncbi.nlm.nih.gov/pubmed/36579067 http://dx.doi.org/10.3389/fpubh.2022.1066899 |
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