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Role of omega-3 fatty acids in the prevention and treatment of cardiovascular Diseases: A consensus statement from the Experts’ Committee Of National Society Of Cardiometabolic Medicine

Low-density lipoprotein cholesterol (LDL-C) has been considered as the primary target for the prevention and treatment of atherosclerotic cardiovascular disease (ASCVD). However, there are still residual cardiovascular risks in some patients even if LDL-C achieves the target level. Emerging evidence...

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Autores principales: Li, Jian-Jun, Dou, Ke-Fei, Zhou, Zhi-Guang, Zhao, Dong, Ye, Ping, Zhao, Jia-Jun, Guo, Li-Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791266/
https://www.ncbi.nlm.nih.gov/pubmed/36578548
http://dx.doi.org/10.3389/fphar.2022.1069992
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author Li, Jian-Jun
Dou, Ke-Fei
Zhou, Zhi-Guang
Zhao, Dong
Ye, Ping
Zhao, Jia-Jun
Guo, Li-Xin
author_facet Li, Jian-Jun
Dou, Ke-Fei
Zhou, Zhi-Guang
Zhao, Dong
Ye, Ping
Zhao, Jia-Jun
Guo, Li-Xin
author_sort Li, Jian-Jun
collection PubMed
description Low-density lipoprotein cholesterol (LDL-C) has been considered as the primary target for the prevention and treatment of atherosclerotic cardiovascular disease (ASCVD). However, there are still residual cardiovascular risks in some patients even if LDL-C achieves the target level. Emerging evidence suggestes that elevated triglyceride (TG) level or triglyceride-rich lipoprotein (TRL) cholesterol (TRL-C) is one of the important components of the residual cardiovascular risks. Omega-3 fatty acids have been shown to be one of the effective drugs for reducing TG. However, its efficacy in reducing the risk of ASCVD is inconsistent in large randomized clinical trials. There is lack of consensus among Experts regarding the application of omega-3 fatty acids in cardiovascular diseases including heart failure, arrhythmia, cardiomyopathy, hypertension, and sudden death. Hence, the current consensus will comprehensively and scientifically present the detailed knowledge about the omega-3 fatty acids from a variety of aspects to provide a reference for its management of omega-3 fatty acids application in the Chinese population.
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spelling pubmed-97912662022-12-27 Role of omega-3 fatty acids in the prevention and treatment of cardiovascular Diseases: A consensus statement from the Experts’ Committee Of National Society Of Cardiometabolic Medicine Li, Jian-Jun Dou, Ke-Fei Zhou, Zhi-Guang Zhao, Dong Ye, Ping Zhao, Jia-Jun Guo, Li-Xin Front Pharmacol Pharmacology Low-density lipoprotein cholesterol (LDL-C) has been considered as the primary target for the prevention and treatment of atherosclerotic cardiovascular disease (ASCVD). However, there are still residual cardiovascular risks in some patients even if LDL-C achieves the target level. Emerging evidence suggestes that elevated triglyceride (TG) level or triglyceride-rich lipoprotein (TRL) cholesterol (TRL-C) is one of the important components of the residual cardiovascular risks. Omega-3 fatty acids have been shown to be one of the effective drugs for reducing TG. However, its efficacy in reducing the risk of ASCVD is inconsistent in large randomized clinical trials. There is lack of consensus among Experts regarding the application of omega-3 fatty acids in cardiovascular diseases including heart failure, arrhythmia, cardiomyopathy, hypertension, and sudden death. Hence, the current consensus will comprehensively and scientifically present the detailed knowledge about the omega-3 fatty acids from a variety of aspects to provide a reference for its management of omega-3 fatty acids application in the Chinese population. Frontiers Media S.A. 2022-12-12 /pmc/articles/PMC9791266/ /pubmed/36578548 http://dx.doi.org/10.3389/fphar.2022.1069992 Text en Copyright © 2022 Li, Dou, Zhou, Zhao, Ye, Zhao and Guo. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Li, Jian-Jun
Dou, Ke-Fei
Zhou, Zhi-Guang
Zhao, Dong
Ye, Ping
Zhao, Jia-Jun
Guo, Li-Xin
Role of omega-3 fatty acids in the prevention and treatment of cardiovascular Diseases: A consensus statement from the Experts’ Committee Of National Society Of Cardiometabolic Medicine
title Role of omega-3 fatty acids in the prevention and treatment of cardiovascular Diseases: A consensus statement from the Experts’ Committee Of National Society Of Cardiometabolic Medicine
title_full Role of omega-3 fatty acids in the prevention and treatment of cardiovascular Diseases: A consensus statement from the Experts’ Committee Of National Society Of Cardiometabolic Medicine
title_fullStr Role of omega-3 fatty acids in the prevention and treatment of cardiovascular Diseases: A consensus statement from the Experts’ Committee Of National Society Of Cardiometabolic Medicine
title_full_unstemmed Role of omega-3 fatty acids in the prevention and treatment of cardiovascular Diseases: A consensus statement from the Experts’ Committee Of National Society Of Cardiometabolic Medicine
title_short Role of omega-3 fatty acids in the prevention and treatment of cardiovascular Diseases: A consensus statement from the Experts’ Committee Of National Society Of Cardiometabolic Medicine
title_sort role of omega-3 fatty acids in the prevention and treatment of cardiovascular diseases: a consensus statement from the experts’ committee of national society of cardiometabolic medicine
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791266/
https://www.ncbi.nlm.nih.gov/pubmed/36578548
http://dx.doi.org/10.3389/fphar.2022.1069992
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