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Network Topology Can Explain Differences in Pleiotropy Between Cis- and Trans-regulatory Mutations
A mutation's degree of pleiotropy (i.e., the number of traits it alters) is predicted to impact the probability of the mutation being detrimental to fitness. For mutations that impact gene expression, mutations acting in cis have been hypothesized to generally be less pleiotropic than mutations...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791367/ https://www.ncbi.nlm.nih.gov/pubmed/36508350 http://dx.doi.org/10.1093/molbev/msac266 |