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PP4 inhibition sensitizes ovarian cancer to NK cell-mediated cytotoxicity via STAT1 activation and inflammatory signaling

BACKGROUND: Increased infiltration of T cells into ovarian tumors has been repeatedly shown to be predictive of enhanced patient survival. However, despite the evidence of an active immune response in ovarian cancer (OC), the frequency of responses to immune checkpoint blockade (ICB) therapy in OC i...

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Detalles Bibliográficos
Autores principales:	Raja, Remya, Wu, Christopher, Bassoy, Esen Yonca, Rubino, Thomas E, Utagawa, Emma C, Magtibay, Paul M, Butler, Kristina A, Curtis, Marion
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2022
Materias:	Basic Tumor Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791393/ https://www.ncbi.nlm.nih.gov/pubmed/36564125 http://dx.doi.org/10.1136/jitc-2022-005026

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