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Clinical outcome using a modified treat-and-extend protocol for neovascular age-related macular degeneration
AIM: To compare outcome between patients treated using a modified treat-and-extend (mT&E) protocol and patients treated using a conventional T&E protocol. METHODS: A retrospective cohort study of two groups of treatment-naïve neovascular age-related macular degeneration patients within a sin...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BMJ Publishing Group
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791424/ https://www.ncbi.nlm.nih.gov/pubmed/37585239 http://dx.doi.org/10.1136/bmjophth-2022-001180 |
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author | Vofo, Brice Nguedia Cnaany, Yaacov Chowers, I |
author_facet | Vofo, Brice Nguedia Cnaany, Yaacov Chowers, I |
author_sort | Vofo, Brice Nguedia |
collection | PubMed |
description | AIM: To compare outcome between patients treated using a modified treat-and-extend (mT&E) protocol and patients treated using a conventional T&E protocol. METHODS: A retrospective cohort study of two groups of treatment-naïve neovascular age-related macular degeneration patients within a single centre were evaluated. One group treated using the conventional T&E protocol, with visual acuity, dilated fundus examination (DFE) and optical coherence tomography (OCT) performed at each visit. The second group treated using the mT&E protocol in which visual acuity and DFE were performed only every three visits. The main outcome measures were time spent per clinical visit, visual and anatomical outcomes measured for 36 months. RESULTS: The T&E and mT&E groups included 135 eyes in 116 patients and 119 eyes in 94 patients, respectively, with similar baseline characteristics. At 36 months, the number of injections administered (7.9±2.9 vs 8.1±2.3 injections, respectively; p=0.55), the percentage of eyes that gained ≥15 Early Treatment for Diabetic Retinopathy Study (ETDRS) letters (23% vs 25.2%, respectively; p=0.39) and the percentage of eyes that lost ≥15 ETDRS letters (21.5% vs 17.7%; p=0.43, respectively) were similar between the T&E and mT&E groups. However, waiting and contact time were reduced during the OCT-only visits compared with the full visits, with an average of 41 min saved per patient encounter. CONCLUSIONS: Both protocols yielded similar visual and anatomical outcomes. However, the mT&E protocol reduced the number of full visits, with considerably less time spent at the clinic. |
format | Online Article Text |
id | pubmed-9791424 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-97914242022-12-27 Clinical outcome using a modified treat-and-extend protocol for neovascular age-related macular degeneration Vofo, Brice Nguedia Cnaany, Yaacov Chowers, I BMJ Open Ophthalmol Retina AIM: To compare outcome between patients treated using a modified treat-and-extend (mT&E) protocol and patients treated using a conventional T&E protocol. METHODS: A retrospective cohort study of two groups of treatment-naïve neovascular age-related macular degeneration patients within a single centre were evaluated. One group treated using the conventional T&E protocol, with visual acuity, dilated fundus examination (DFE) and optical coherence tomography (OCT) performed at each visit. The second group treated using the mT&E protocol in which visual acuity and DFE were performed only every three visits. The main outcome measures were time spent per clinical visit, visual and anatomical outcomes measured for 36 months. RESULTS: The T&E and mT&E groups included 135 eyes in 116 patients and 119 eyes in 94 patients, respectively, with similar baseline characteristics. At 36 months, the number of injections administered (7.9±2.9 vs 8.1±2.3 injections, respectively; p=0.55), the percentage of eyes that gained ≥15 Early Treatment for Diabetic Retinopathy Study (ETDRS) letters (23% vs 25.2%, respectively; p=0.39) and the percentage of eyes that lost ≥15 ETDRS letters (21.5% vs 17.7%; p=0.43, respectively) were similar between the T&E and mT&E groups. However, waiting and contact time were reduced during the OCT-only visits compared with the full visits, with an average of 41 min saved per patient encounter. CONCLUSIONS: Both protocols yielded similar visual and anatomical outcomes. However, the mT&E protocol reduced the number of full visits, with considerably less time spent at the clinic. BMJ Publishing Group 2022-12-23 /pmc/articles/PMC9791424/ /pubmed/37585239 http://dx.doi.org/10.1136/bmjophth-2022-001180 Text en © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Retina Vofo, Brice Nguedia Cnaany, Yaacov Chowers, I Clinical outcome using a modified treat-and-extend protocol for neovascular age-related macular degeneration |
title | Clinical outcome using a modified treat-and-extend protocol for neovascular age-related macular degeneration |
title_full | Clinical outcome using a modified treat-and-extend protocol for neovascular age-related macular degeneration |
title_fullStr | Clinical outcome using a modified treat-and-extend protocol for neovascular age-related macular degeneration |
title_full_unstemmed | Clinical outcome using a modified treat-and-extend protocol for neovascular age-related macular degeneration |
title_short | Clinical outcome using a modified treat-and-extend protocol for neovascular age-related macular degeneration |
title_sort | clinical outcome using a modified treat-and-extend protocol for neovascular age-related macular degeneration |
topic | Retina |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791424/ https://www.ncbi.nlm.nih.gov/pubmed/37585239 http://dx.doi.org/10.1136/bmjophth-2022-001180 |
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