An autophagy-inducing stapled peptide promotes c-MET degradation and overrides adaptive resistance to sorafenib in c-MET(+) hepatocellular carcinoma

BACKGROUND: Hepatocellular carcinoma (HCC) accounts for approximately 90% of primary liver cancer cases and ranks as the second leading cause of cancer related death. Multiple receptor tyrosine kinases such as EGFR, FGFR and c-MET have been shown to drive tumorigenesis and progression of HCC. Howeve...

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Detalles Bibliográficos
Autores principales: Gao, Shan, Li, Na, Zhang, Xiaozhe, Chen, Jingyi, Ko, Ben C.B., Zhao, Yanxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791588/
https://www.ncbi.nlm.nih.gov/pubmed/36578529
http://dx.doi.org/10.1016/j.bbrep.2022.101412

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791588/
https://www.ncbi.nlm.nih.gov/pubmed/36578529
http://dx.doi.org/10.1016/j.bbrep.2022.101412

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