Tandem Palladium/Copper-Catalyzed Decarboxylative Approach to Benzoimidazo- and Imidazophenanthridine Skeletons

[Image: see text] A protocol for a tandem Pd/Cu-catalyzed intermolecular cross-coupling cascade between o-bromobenzoic acids and 2-(2-bromoaryl)-1H-benzo[d]imidazoles or the corresponding imidazoles is presented. The protocol provides conceptually novel and controlled access to synthetically useful...

Descripción completa

Detalles Bibliográficos
Autores principales: Geng, Xin, Shatskiy, Andrey, Alvey, Gregory R., Liu, Jian-Quan, Kärkäs, Markus D., Wang, Xiang-Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791681/
https://www.ncbi.nlm.nih.gov/pubmed/36512690
http://dx.doi.org/10.1021/acs.orglett.2c03647
_version_ 1784859461097095168
author Geng, Xin
Shatskiy, Andrey
Alvey, Gregory R.
Liu, Jian-Quan
Kärkäs, Markus D.
Wang, Xiang-Shan
author_facet Geng, Xin
Shatskiy, Andrey
Alvey, Gregory R.
Liu, Jian-Quan
Kärkäs, Markus D.
Wang, Xiang-Shan
author_sort Geng, Xin
collection PubMed
description [Image: see text] A protocol for a tandem Pd/Cu-catalyzed intermolecular cross-coupling cascade between o-bromobenzoic acids and 2-(2-bromoaryl)-1H-benzo[d]imidazoles or the corresponding imidazoles is presented. The protocol provides conceptually novel and controlled access to synthetically useful N-fused (benzo)imidazophenanthridine scaffolds with high efficiency, a broad substrate scope, and excellent functional group compatibility.
format Online
Article
Text
id pubmed-9791681
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher American Chemical Society
record_format MEDLINE/PubMed
spelling pubmed-97916812022-12-27 Tandem Palladium/Copper-Catalyzed Decarboxylative Approach to Benzoimidazo- and Imidazophenanthridine Skeletons Geng, Xin Shatskiy, Andrey Alvey, Gregory R. Liu, Jian-Quan Kärkäs, Markus D. Wang, Xiang-Shan Org Lett [Image: see text] A protocol for a tandem Pd/Cu-catalyzed intermolecular cross-coupling cascade between o-bromobenzoic acids and 2-(2-bromoaryl)-1H-benzo[d]imidazoles or the corresponding imidazoles is presented. The protocol provides conceptually novel and controlled access to synthetically useful N-fused (benzo)imidazophenanthridine scaffolds with high efficiency, a broad substrate scope, and excellent functional group compatibility. American Chemical Society 2022-12-13 2022-12-23 /pmc/articles/PMC9791681/ /pubmed/36512690 http://dx.doi.org/10.1021/acs.orglett.2c03647 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Geng, Xin
Shatskiy, Andrey
Alvey, Gregory R.
Liu, Jian-Quan
Kärkäs, Markus D.
Wang, Xiang-Shan
Tandem Palladium/Copper-Catalyzed Decarboxylative Approach to Benzoimidazo- and Imidazophenanthridine Skeletons
title Tandem Palladium/Copper-Catalyzed Decarboxylative Approach to Benzoimidazo- and Imidazophenanthridine Skeletons
title_full Tandem Palladium/Copper-Catalyzed Decarboxylative Approach to Benzoimidazo- and Imidazophenanthridine Skeletons
title_fullStr Tandem Palladium/Copper-Catalyzed Decarboxylative Approach to Benzoimidazo- and Imidazophenanthridine Skeletons
title_full_unstemmed Tandem Palladium/Copper-Catalyzed Decarboxylative Approach to Benzoimidazo- and Imidazophenanthridine Skeletons
title_short Tandem Palladium/Copper-Catalyzed Decarboxylative Approach to Benzoimidazo- and Imidazophenanthridine Skeletons
title_sort tandem palladium/copper-catalyzed decarboxylative approach to benzoimidazo- and imidazophenanthridine skeletons
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791681/
https://www.ncbi.nlm.nih.gov/pubmed/36512690
http://dx.doi.org/10.1021/acs.orglett.2c03647
work_keys_str_mv AT gengxin tandempalladiumcoppercatalyzeddecarboxylativeapproachtobenzoimidazoandimidazophenanthridineskeletons
AT shatskiyandrey tandempalladiumcoppercatalyzeddecarboxylativeapproachtobenzoimidazoandimidazophenanthridineskeletons
AT alveygregoryr tandempalladiumcoppercatalyzeddecarboxylativeapproachtobenzoimidazoandimidazophenanthridineskeletons
AT liujianquan tandempalladiumcoppercatalyzeddecarboxylativeapproachtobenzoimidazoandimidazophenanthridineskeletons
AT karkasmarkusd tandempalladiumcoppercatalyzeddecarboxylativeapproachtobenzoimidazoandimidazophenanthridineskeletons
AT wangxiangshan tandempalladiumcoppercatalyzeddecarboxylativeapproachtobenzoimidazoandimidazophenanthridineskeletons

Ejemplares similares