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Zebrafish models for glucocorticoid-induced osteoporosis
Glucocorticoid-induced osteoporosis (GIOP) is the most common form of secondary osteoporosis due to excessive or long-term glucocorticoid administration, disturbing the homeostasis between bone formation and bone resorption. The bone biology of zebrafish shares a high degree of similarities with mam...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791848/ https://www.ncbi.nlm.nih.gov/pubmed/36578638 http://dx.doi.org/10.4103/tcmj.tcmj_80_22 |
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author | Lin, Wen-Ying Dharini, Kameshwara Kumar Peng, Cheng-Huan Lin, Chung-Yen Yeh, Kuang-Ting Lee, Wen-Chih Lin, Ming-Der |
author_facet | Lin, Wen-Ying Dharini, Kameshwara Kumar Peng, Cheng-Huan Lin, Chung-Yen Yeh, Kuang-Ting Lee, Wen-Chih Lin, Ming-Der |
author_sort | Lin, Wen-Ying |
collection | PubMed |
description | Glucocorticoid-induced osteoporosis (GIOP) is the most common form of secondary osteoporosis due to excessive or long-term glucocorticoid administration, disturbing the homeostasis between bone formation and bone resorption. The bone biology of zebrafish shares a high degree of similarities with mammals. In terms of molecular level, genes and signaling pathways related to skeletogenesis are also highly correlated between zebrafish and humans. Therefore, zebrafish have been utilized to develop multiple GIOP models. Taking advantage of the transparency of zebrafish larvae, their skeletal development and bone mineralization can be readily visualized through in vivo staining without invasive experimental handlings. Moreover, the feasibility of using scales or fin rays to study bone remodeling makes adult zebrafish an ideal model for GIOP research. Here, we reviewed current zebrafish models for GIOP research, focused on the tools and methods established for examining bone homeostasis. As an in vivo, convenient, and robust model, zebrafish have an advantage in performing high-throughput drug screening and could be used to investigate the action mechanisms of therapeutic drugs. |
format | Online Article Text |
id | pubmed-9791848 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-97918482022-12-27 Zebrafish models for glucocorticoid-induced osteoporosis Lin, Wen-Ying Dharini, Kameshwara Kumar Peng, Cheng-Huan Lin, Chung-Yen Yeh, Kuang-Ting Lee, Wen-Chih Lin, Ming-Der Tzu Chi Med J Review Article Glucocorticoid-induced osteoporosis (GIOP) is the most common form of secondary osteoporosis due to excessive or long-term glucocorticoid administration, disturbing the homeostasis between bone formation and bone resorption. The bone biology of zebrafish shares a high degree of similarities with mammals. In terms of molecular level, genes and signaling pathways related to skeletogenesis are also highly correlated between zebrafish and humans. Therefore, zebrafish have been utilized to develop multiple GIOP models. Taking advantage of the transparency of zebrafish larvae, their skeletal development and bone mineralization can be readily visualized through in vivo staining without invasive experimental handlings. Moreover, the feasibility of using scales or fin rays to study bone remodeling makes adult zebrafish an ideal model for GIOP research. Here, we reviewed current zebrafish models for GIOP research, focused on the tools and methods established for examining bone homeostasis. As an in vivo, convenient, and robust model, zebrafish have an advantage in performing high-throughput drug screening and could be used to investigate the action mechanisms of therapeutic drugs. Wolters Kluwer - Medknow 2022-08-23 /pmc/articles/PMC9791848/ /pubmed/36578638 http://dx.doi.org/10.4103/tcmj.tcmj_80_22 Text en Copyright: © 2022 Tzu Chi Medical Journal https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Review Article Lin, Wen-Ying Dharini, Kameshwara Kumar Peng, Cheng-Huan Lin, Chung-Yen Yeh, Kuang-Ting Lee, Wen-Chih Lin, Ming-Der Zebrafish models for glucocorticoid-induced osteoporosis |
title | Zebrafish models for glucocorticoid-induced osteoporosis |
title_full | Zebrafish models for glucocorticoid-induced osteoporosis |
title_fullStr | Zebrafish models for glucocorticoid-induced osteoporosis |
title_full_unstemmed | Zebrafish models for glucocorticoid-induced osteoporosis |
title_short | Zebrafish models for glucocorticoid-induced osteoporosis |
title_sort | zebrafish models for glucocorticoid-induced osteoporosis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791848/ https://www.ncbi.nlm.nih.gov/pubmed/36578638 http://dx.doi.org/10.4103/tcmj.tcmj_80_22 |
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