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In-Office Needle Arthroscopic Synovial Biopsy Is an Effective Diagnostic Tool in Patients With Inflammatory Arthritis

PURPOSE: To assess the utility, safety, and accuracy of in-office needle arthroscopic (IONA) synovial biopsy as a diagnostic tool during treatment of drug-resistant monoarticular inflammatory arthritis of the knee. METHODS: Consecutive patients diagnosed with rheumatoid or psoriatic arthritis with t...

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Autores principales: Andreozzi, Valerio, Monaco, Edoardo, Garufi, Cristina, Spinelli, Francesca Romana, Rossi, Giorgio, Dagget, Matthew, Conti, Fabrizio, Ferretti, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791868/
https://www.ncbi.nlm.nih.gov/pubmed/36579034
http://dx.doi.org/10.1016/j.asmr.2022.10.003
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author Andreozzi, Valerio
Monaco, Edoardo
Garufi, Cristina
Spinelli, Francesca Romana
Rossi, Giorgio
Dagget, Matthew
Conti, Fabrizio
Ferretti, Andrea
author_facet Andreozzi, Valerio
Monaco, Edoardo
Garufi, Cristina
Spinelli, Francesca Romana
Rossi, Giorgio
Dagget, Matthew
Conti, Fabrizio
Ferretti, Andrea
author_sort Andreozzi, Valerio
collection PubMed
description PURPOSE: To assess the utility, safety, and accuracy of in-office needle arthroscopic (IONA) synovial biopsy as a diagnostic tool during treatment of drug-resistant monoarticular inflammatory arthritis of the knee. METHODS: Consecutive patients diagnosed with rheumatoid or psoriatic arthritis with treatment-resistant monoarticular knee involvement who underwent in-office needle arthroscopic synovial biopsy were considered for inclusion. The exclusion criteria were any current malignancies or infection. All patients underwent systematic physical and laboratory examination. IONA was undertaken to inspect the macroscopic appearance of the joint, choose the biopsy site, and classify synovial inflammation. Once collected, synovial tissue specimens were examined histologically using the Krenn scoring system. RESULTS: In total, 12 patients (9 male and 3 female, median age 57 [interquartile range {IQR} 8] years, median disease duration 156 [IQR 201] months) affected by psoriatic arthritis (n = 6) or rheumatoid arthritis (n = 6) were included in this study. Median operating time was 12 (IQR 11) minutes. Three biopsies per patient were collected. The success rate of specimen collection was 97%, the median postoperative 0-10 visual analog scale pain score was 2 (IQR 3), and only one minor complication occurred. CONCLUSIONS: Knee IONA with synovial biopsy is an effective and well-tolerated procedure that can help clinicians formulate specific treatment strategies in patients with refractory pain in the setting of rheumatoid and psoriatic arthritis. LEVEL OF EVIDENCE: IV, Therapeutic case series.
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spelling pubmed-97918682022-12-27 In-Office Needle Arthroscopic Synovial Biopsy Is an Effective Diagnostic Tool in Patients With Inflammatory Arthritis Andreozzi, Valerio Monaco, Edoardo Garufi, Cristina Spinelli, Francesca Romana Rossi, Giorgio Dagget, Matthew Conti, Fabrizio Ferretti, Andrea Arthrosc Sports Med Rehabil Original Article PURPOSE: To assess the utility, safety, and accuracy of in-office needle arthroscopic (IONA) synovial biopsy as a diagnostic tool during treatment of drug-resistant monoarticular inflammatory arthritis of the knee. METHODS: Consecutive patients diagnosed with rheumatoid or psoriatic arthritis with treatment-resistant monoarticular knee involvement who underwent in-office needle arthroscopic synovial biopsy were considered for inclusion. The exclusion criteria were any current malignancies or infection. All patients underwent systematic physical and laboratory examination. IONA was undertaken to inspect the macroscopic appearance of the joint, choose the biopsy site, and classify synovial inflammation. Once collected, synovial tissue specimens were examined histologically using the Krenn scoring system. RESULTS: In total, 12 patients (9 male and 3 female, median age 57 [interquartile range {IQR} 8] years, median disease duration 156 [IQR 201] months) affected by psoriatic arthritis (n = 6) or rheumatoid arthritis (n = 6) were included in this study. Median operating time was 12 (IQR 11) minutes. Three biopsies per patient were collected. The success rate of specimen collection was 97%, the median postoperative 0-10 visual analog scale pain score was 2 (IQR 3), and only one minor complication occurred. CONCLUSIONS: Knee IONA with synovial biopsy is an effective and well-tolerated procedure that can help clinicians formulate specific treatment strategies in patients with refractory pain in the setting of rheumatoid and psoriatic arthritis. LEVEL OF EVIDENCE: IV, Therapeutic case series. Elsevier 2022-11-29 /pmc/articles/PMC9791868/ /pubmed/36579034 http://dx.doi.org/10.1016/j.asmr.2022.10.003 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Andreozzi, Valerio
Monaco, Edoardo
Garufi, Cristina
Spinelli, Francesca Romana
Rossi, Giorgio
Dagget, Matthew
Conti, Fabrizio
Ferretti, Andrea
In-Office Needle Arthroscopic Synovial Biopsy Is an Effective Diagnostic Tool in Patients With Inflammatory Arthritis
title In-Office Needle Arthroscopic Synovial Biopsy Is an Effective Diagnostic Tool in Patients With Inflammatory Arthritis
title_full In-Office Needle Arthroscopic Synovial Biopsy Is an Effective Diagnostic Tool in Patients With Inflammatory Arthritis
title_fullStr In-Office Needle Arthroscopic Synovial Biopsy Is an Effective Diagnostic Tool in Patients With Inflammatory Arthritis
title_full_unstemmed In-Office Needle Arthroscopic Synovial Biopsy Is an Effective Diagnostic Tool in Patients With Inflammatory Arthritis
title_short In-Office Needle Arthroscopic Synovial Biopsy Is an Effective Diagnostic Tool in Patients With Inflammatory Arthritis
title_sort in-office needle arthroscopic synovial biopsy is an effective diagnostic tool in patients with inflammatory arthritis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791868/
https://www.ncbi.nlm.nih.gov/pubmed/36579034
http://dx.doi.org/10.1016/j.asmr.2022.10.003
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