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Recent Update on Immunopathogenesis of Psoriasis

Psoriasis is a chronic disabling complex inflammatory disorder prevalent worldwide with environmental and genetic components that involve predominantly skin in addition to nails and joints associated with various systemic comorbidities having periods of exacerbations and remissions. Psoriasis is cha...

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Detalles Bibliográficos
Autores principales: Chhabra, Seema, Dogra, Sunil, Sharma, Keshav, Raychaudhuri, Smriti K., Raychaudhuri, Siba P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792009/
https://www.ncbi.nlm.nih.gov/pubmed/36578729
http://dx.doi.org/10.4103/ijd.ijd_569_22
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author Chhabra, Seema
Dogra, Sunil
Sharma, Keshav
Raychaudhuri, Smriti K.
Raychaudhuri, Siba P.
author_facet Chhabra, Seema
Dogra, Sunil
Sharma, Keshav
Raychaudhuri, Smriti K.
Raychaudhuri, Siba P.
author_sort Chhabra, Seema
collection PubMed
description Psoriasis is a chronic disabling complex inflammatory disorder prevalent worldwide with environmental and genetic components that involve predominantly skin in addition to nails and joints associated with various systemic comorbidities having periods of exacerbations and remissions. Psoriasis is characterized by hyper-proliferation as well as abnormal differentiation of epidermal keratinocytes and lymphocyte infiltration (mainly T cells) with resultant inflammatory cytokines and chemokines. Immunological and genetic studies over the last decade have identified genetic susceptibility risk alleles, molecular, cellular and immunological mechanisms involved in immunopathogenesis of psoriasis. The current disease model emphasizes the role of aberrant Th1 and Th17 responses regulated by a complex network of different cytokines, including TNF-α, IL-17 and IL-23; signal transduction pathways downstream to the cytokine receptors; and various activated transcription factors, including NF-κB, interferon regulatory factors and signal transducer and activator of transcriptions. Cytokines targeting biologics (IL-17, IL-23 and TNFα) therapies have revolutionized the management of severe skin disease having beneficial effects on joints and systemic inflammation of psoriasis as well. Further better understanding of immunopathogenesis of psoriasis will pave way for precision medicine based on specific immunopathogenic targets in a given phenotype of disease. Complex interplay of psoriasis with associated comorbidities is also a future area of research for overall better patient management and to improve their quality of life.
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spelling pubmed-97920092022-12-27 Recent Update on Immunopathogenesis of Psoriasis Chhabra, Seema Dogra, Sunil Sharma, Keshav Raychaudhuri, Smriti K. Raychaudhuri, Siba P. Indian J Dermatol IJD Symposium Psoriasis is a chronic disabling complex inflammatory disorder prevalent worldwide with environmental and genetic components that involve predominantly skin in addition to nails and joints associated with various systemic comorbidities having periods of exacerbations and remissions. Psoriasis is characterized by hyper-proliferation as well as abnormal differentiation of epidermal keratinocytes and lymphocyte infiltration (mainly T cells) with resultant inflammatory cytokines and chemokines. Immunological and genetic studies over the last decade have identified genetic susceptibility risk alleles, molecular, cellular and immunological mechanisms involved in immunopathogenesis of psoriasis. The current disease model emphasizes the role of aberrant Th1 and Th17 responses regulated by a complex network of different cytokines, including TNF-α, IL-17 and IL-23; signal transduction pathways downstream to the cytokine receptors; and various activated transcription factors, including NF-κB, interferon regulatory factors and signal transducer and activator of transcriptions. Cytokines targeting biologics (IL-17, IL-23 and TNFα) therapies have revolutionized the management of severe skin disease having beneficial effects on joints and systemic inflammation of psoriasis as well. Further better understanding of immunopathogenesis of psoriasis will pave way for precision medicine based on specific immunopathogenic targets in a given phenotype of disease. Complex interplay of psoriasis with associated comorbidities is also a future area of research for overall better patient management and to improve their quality of life. Wolters Kluwer - Medknow 2022 /pmc/articles/PMC9792009/ /pubmed/36578729 http://dx.doi.org/10.4103/ijd.ijd_569_22 Text en Copyright: © 2022 Indian Journal of Dermatology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle IJD Symposium
Chhabra, Seema
Dogra, Sunil
Sharma, Keshav
Raychaudhuri, Smriti K.
Raychaudhuri, Siba P.
Recent Update on Immunopathogenesis of Psoriasis
title Recent Update on Immunopathogenesis of Psoriasis
title_full Recent Update on Immunopathogenesis of Psoriasis
title_fullStr Recent Update on Immunopathogenesis of Psoriasis
title_full_unstemmed Recent Update on Immunopathogenesis of Psoriasis
title_short Recent Update on Immunopathogenesis of Psoriasis
title_sort recent update on immunopathogenesis of psoriasis
topic IJD Symposium
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792009/
https://www.ncbi.nlm.nih.gov/pubmed/36578729
http://dx.doi.org/10.4103/ijd.ijd_569_22
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