Cargando…

Identifying the molecular mechanisms of sepsis-associated acute kidney injury and predicting potential drugs

Objective: To provide insights into the diagnosis and therapy of SA-AKI via ferroptosis genes. Methods: Based on three datasets (GSE57065, GSE30718, and GSE53771), we used weighted co-expression network analysis to identify the key regulators of SA-AKI, its potential biological functions, and constr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Guo, Guangfeng, Wang, Yunting, Kou, Wanyu, Gan, Hua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792148/ https://www.ncbi.nlm.nih.gov/pubmed/36579331 http://dx.doi.org/10.3389/fgene.2022.1062293

Ejemplares similares

Effect of sodium bicarbonate infusion on hospital mortality in acute kidney injury patients with metabolic acidosis
por: Wang, Yunting, et al.
Publicado: (2023)

Identification and Validation of Potential Biomarkers and Their Functions in Acute Kidney Injury
por: Chen, Jianwen, et al.
Publicado: (2020)

Bioinformatics Analysis Identifies Molecular Markers Regulating Development and Progression of Endometriosis and Potential Therapeutic Drugs
por: Peng, Ying, et al.
Publicado: (2021)

Potential mechanism and drug candidates for sepsis-induced acute lung injury
por: Xu, Chenyuan, et al.
Publicado: (2018)

PICK1 Deficiency Exacerbates Sepsis-Associated Acute Kidney Injury
por: Dou, Qian, et al.
Publicado: (2021)

Erratum to “PICK1 Deficiency Exacerbates Sepsis-Associated Acute Kidney Injury”
por: Dou, Qian, et al.
Publicado: (2022)

Mechanisms underlying the therapeutic effects of 4-octyl itaconate in treating sepsis based on network pharmacology and molecular docking
por: Chen, Maolin, et al.
Publicado: (2022)

Metabolomics Analysis of the Development of Sepsis and Potential Biomarkers of Sepsis-Induced Acute Kidney Injury
por: Ping, Feng, et al.
Publicado: (2021)

Multi-Omics Approach Identifies Molecular Mechanisms of Plant-Fungus Mycorrhizal Interaction
por: Larsen, Peter E., et al.
Publicado: (2016)

The use of multiple datasets to identify autophagy-related molecular mechanisms in intracerebral hemorrhage
por: Xiao, Yinggang, et al.
Publicado: (2023)

A bioinformatics framework to identify the biomarkers and potential drugs for the treatment of colorectal cancer
por: Leng, Xiaogang, et al.
Publicado: (2022)

The Clinical Significance and Potential Molecular Mechanism of PTTG1 in Esophageal Squamous Cell Carcinoma
por: Chen, Shang-Wei, et al.
Publicado: (2021)

From Surviving Sepsis to Surviving Sepsis-Associated Acute Kidney Injury: Focusing on Risk Stratification of Acute Kidney Injury / Acute Kidney Disease After Sepsis
por: Kothari, Niraj R., et al.
Publicado: (2021)

Genetic predisposition may not improve prediction of cardiac surgery-associated acute kidney injury
por: Douville, Nicholas J., et al.
Publicado: (2023)

Drug Discovery in Spinal Cord Injury With Ankylosing Spondylitis Identified by Text Mining and Biomedical Databases
por: Wang, Chenfeng, et al.
Publicado: (2022)

Ferroptosis and Acute Kidney Injury (AKI): Molecular Mechanisms and Therapeutic Potentials
por: Feng, Qi, et al.
Publicado: (2022)

Sepsis-induced acute kidney injury
por: Majumdar, Arghya
Publicado: (2010)

A Computational Framework to Identify Biomarkers for Glioma Recurrence and Potential Drugs Targeting Them
por: Ma, Shuzhi, et al.
Publicado: (2022)

The early diagnosis and pathogenic mechanisms of sepsis-related acute kidney injury
por: Wei, Wei, et al.
Publicado: (2023)

Acute Kidney Injury From Biopsy-Proven Renal Oxalosis From Excessive Intake of Vitamin C Leading to End-Stage Kidney Disease
por: Williams, Ryan, et al.
Publicado: (2022)

Use of Biomarkers to Identify Acute Kidney Injury to Help Detect Sepsis in Patients With Infection
por: Kellum, John A., et al.
Publicado: (2021)

Comprehensive Network-Based Analyses Reveal Novel Renal Function-Related Targets in Acute Kidney Injury
por: Zhang, Yang, et al.
Publicado: (2022)

Comprehensive Analysis of Molecular Subtypes and Hub Genes of Sepsis by Gene Expression Profiles
por: Lai, Yongxing, et al.
Publicado: (2022)

Molecular differences in susceptibility of the kidney to sepsis-induced kidney injury
por: Matejovic, Martin, et al.
Publicado: (2017)

Gene expression profiling of sepsis-associated acute kidney injury
por: Yang, Jing-Juan, et al.
Publicado: (2020)

Integrated Analysis of m6A Methylome in Cisplatin-Induced Acute Kidney Injury and Berberine Alleviation in Mouse
por: Shen, Jianxiao, et al.
Publicado: (2020)

Myopathic Carnitine Palmitoyltransferase II (CPT II) Deficiency: A Rare Cause of Acute Kidney Injury and Cardiomyopathy
por: Castillo, Efrain, et al.
Publicado: (2023)

Acute kidney injury in sepsis: transient or intrinsic?
por: Jörres, Achim
Publicado: (2013)

Biomarkers of Sepsis-Induced Acute Kidney Injury
por: Wang, Kaifei, et al.
Publicado: (2018)

Effects and Mechanism of lncRNA CRNDE on Sepsis-Induced Acute Kidney Injury
por: Wu, Shen, et al.
Publicado: (2020)

Identifying potential risk genes and pathways for neuropsychiatric and substance use disorders using intermediate molecular mediator information
por: Gedik, Huseyin, et al.
Publicado: (2023)

Multi-Omics Analysis of Diabetic Nephropathy Reveals Potential New Mechanisms and Drug Targets
por: Sha, Qian, et al.
Publicado: (2020)

Identifying the Patient at Risk for Acute Kidney Injury: Pediatric Sepsis Biomarker Risk Model Study
por: Gien, Jason, et al.
Publicado: (2020)

Corrigendum: Bioinformatics Analysis Identififies Molecular Markers Regulating Development and Progression of Endometriosis and Potential Therapeutic Drugs
por: Peng, Ying, et al.
Publicado: (2022)

Studies on the molecular level changes and potential resistance mechanism of Coreius guichenoti under temperature stimulation
por: Duan, Yuanliang, et al.
Publicado: (2022)

FLT3 Mutations in Acute Myeloid Leukemia: Unraveling the Molecular Mechanisms and Implications for Targeted Therapies
por: Jalte, Meryem, et al.
Publicado: (2023)

Identification of novel key genes and potential candidate small molecule drugs in diabetic kidney disease using comprehensive bioinformatics analysis
por: Li, Bin, et al.
Publicado: (2022)

Analysis of chronic kidney disease patients by targeted next-generation sequencing identifies novel variants in kidney-related genes
por: Alaamery, Manal, et al.
Publicado: (2022)

Molecular Mechanisms of Ferroptosis and Their Involvement in Acute Kidney Injury
por: Liu, Jie, et al.
Publicado: (2023)

Transcriptomic analysis and laboratory experiments reveal potential critical genes and regulatory mechanisms in sepsis-associated acute kidney injury
por: Liu, Boyang, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_hpf2ra69mvb5iup1d1i6jg98dd