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Spatial transcriptomics demonstrates the role of CD4 T cells in effector CD8 T cell differentiation during chronic viral infection

CD4 T cell help is critical to sustain effector CD8 T cell responses during chronic infection, notably via T follicular helper (Tfh)-derived interleukin-21 (IL-21). Conversely, CD4 depletion results in severe CD8 T cell dysfunction and lifelong viremia despite CD4 T cell reemergence following transi...

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Detalles Bibliográficos
Autores principales:	Topchyan, Paytsar, Zander, Ryan, Kasmani, Moujtaba Y., Nguyen, Christine, Brown, Ashley, Lin, Siying, Burns, Robert, Cui, Weiguo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792173/ https://www.ncbi.nlm.nih.gov/pubmed/36450262 http://dx.doi.org/10.1016/j.celrep.2022.111736

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