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Targeting SARS-CoV-2 and host cell receptor interactions

Despite the availability of vaccines and therapeutics, continual genetic alterations render the severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) a persistent threat, particularly for the immunocompromised and elderly. Through interactions of its spike (S) protein with different receptors...

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Autor principal: Lim, Siew Pheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier B.V. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792186/
https://www.ncbi.nlm.nih.gov/pubmed/36581047
http://dx.doi.org/10.1016/j.antiviral.2022.105514
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author Lim, Siew Pheng
author_facet Lim, Siew Pheng
author_sort Lim, Siew Pheng
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description Despite the availability of vaccines and therapeutics, continual genetic alterations render the severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) a persistent threat, particularly for the immunocompromised and elderly. Through interactions of its spike (S) protein with different receptors and coreceptors on host cell surfaces, the virus enters the cell either via fusion with the plasma membrane or through endocytosis. Angiotensin-converting enzyme 2 (ACE2) has been identified as a key receptor utilized by SARS-CoV-2 and related human coronaviruses to mediate cell entry in the lung airways. Auxiliary SARS-CoV-2 entry receptors such as ASGPR1, Kremen protein 1, integrins have also been reported. In this review, therapeutic approaches to block SARS-CoV-2 and host cell receptor interactions are discussed.
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spelling pubmed-97921862022-12-27 Targeting SARS-CoV-2 and host cell receptor interactions Lim, Siew Pheng Antiviral Res Article Despite the availability of vaccines and therapeutics, continual genetic alterations render the severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) a persistent threat, particularly for the immunocompromised and elderly. Through interactions of its spike (S) protein with different receptors and coreceptors on host cell surfaces, the virus enters the cell either via fusion with the plasma membrane or through endocytosis. Angiotensin-converting enzyme 2 (ACE2) has been identified as a key receptor utilized by SARS-CoV-2 and related human coronaviruses to mediate cell entry in the lung airways. Auxiliary SARS-CoV-2 entry receptors such as ASGPR1, Kremen protein 1, integrins have also been reported. In this review, therapeutic approaches to block SARS-CoV-2 and host cell receptor interactions are discussed. Published by Elsevier B.V. 2023-02 2022-12-26 /pmc/articles/PMC9792186/ /pubmed/36581047 http://dx.doi.org/10.1016/j.antiviral.2022.105514 Text en © 2022 Published by Elsevier B.V. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Lim, Siew Pheng
Targeting SARS-CoV-2 and host cell receptor interactions
title Targeting SARS-CoV-2 and host cell receptor interactions
title_full Targeting SARS-CoV-2 and host cell receptor interactions
title_fullStr Targeting SARS-CoV-2 and host cell receptor interactions
title_full_unstemmed Targeting SARS-CoV-2 and host cell receptor interactions
title_short Targeting SARS-CoV-2 and host cell receptor interactions
title_sort targeting sars-cov-2 and host cell receptor interactions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792186/
https://www.ncbi.nlm.nih.gov/pubmed/36581047
http://dx.doi.org/10.1016/j.antiviral.2022.105514
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