Cargando…

Electrophysiological Changes of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes during Acute Hypoxia and Reoxygenation

Ischemic heart disease is the most common cardiovascular disease and a major burden for healthcare worldwide. However, its pathophysiology is still not fully understood, and human-based models for disease mechanisms and treatments are needed. Here, we used human-induced pluripotent stem cell-derived...

Descripción completa

Detalles Bibliográficos
Autores principales:	Häkli, Martta, Kreutzer, Joose, Mäki, Antti-Juhana, Välimäki, Hannu, Cherian, Reeja Maria, Kallio, Pasi, Aalto-Setälä, Katriina, Pekkanen-Mattila, Mari
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792238/ https://www.ncbi.nlm.nih.gov/pubmed/36579142 http://dx.doi.org/10.1155/2022/9438281

Ejemplares similares

Human induced pluripotent stem cell-based platform for modeling cardiac ischemia
por: Häkli, Martta, et al.
Publicado: (2021)

Cardiac Ischemia On-a-Chip: Antiarrhythmic Effect of Levosimendan on Ischemic Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes
por: Gaballah, Mahmoud, et al.
Publicado: (2022)

Fluorescent hiPSC-derived MYH6-mScarlet cardiomyocytes for real-time tracking, imaging, and cardiotoxicity assays
por: Maria Cherian, Reeja, et al.
Publicado: (2022)

Human Neurons Form Axon-Mediated Functional Connections with Human Cardiomyocytes in Compartmentalized Microfluidic Chip
por: Häkli, Martta, et al.
Publicado: (2022)

Pneumatic unidirectional cell stretching device for mechanobiological studies of cardiomyocytes
por: Kreutzer, Joose, et al.
Publicado: (2019)

Compartmentalized organ-on-a-chip structure for spatiotemporal control of oxygen microenvironments
por: Tornberg, Kaisa, et al.
Publicado: (2022)

Polyethylene Terephthalate Textiles Enhance the Structural Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes
por: Pekkanen-Mattila, Mari, et al.
Publicado: (2019)

Covalent immobilization of luminescent oxygen indicators reduces cytotoxicity
por: Välimäki, Hannu, et al.
Publicado: (2020)

Modeling of LMNA-Related Dilated Cardiomyopathy Using Human Induced Pluripotent Stem Cells
por: Shah, Disheet, et al.
Publicado: (2019)

Distinct electrophysiological and mechanical beating phenotypes of long QT syndrome type 1-specific cardiomyocytes carrying different mutations
por: Kiviaho, Anna L., et al.
Publicado: (2015)

Pneumatic equiaxial compression device for mechanical manipulation of epithelial cell packing and physiology
por: Peussa, Heidi, et al.
Publicado: (2022)

Electrical Field Stimulation with a Novel Platform: Effect on Cardiomyocyte Gene Expression but not on Orientation
por: Kujala, Kirsi, et al.
Publicado: (2012)

Cardiac Differentiation of Pluripotent Stem Cells
por: Rajala, Kristiina, et al.
Publicado: (2011)

Maturation of human pluripotent stem cell derived cardiomyocytes is improved in cardiovascular construct
por: Vuorenpää, Hanna, et al.
Publicado: (2017)

HiPSC-derived cardiomyocyte to model Brugada syndrome: both asymptomatic and symptomatic mutation carriers reveal increased arrhythmogenicity
por: Penttinen, Kirsi, et al.
Publicado: (2023)

Mechanically Biomimetic Gelatin–Gellan Gum Hydrogels for 3D Culture of Beating Human Cardiomyocytes
por: Koivisto, Janne T., et al.
Publicado: (2019)

hiPSC-Derived Cardiomyocyte Model of LQT2 Syndrome Derived from Asymptomatic and Symptomatic Mutation Carriers Reproduces Clinical Differences in Aggregates but Not in Single Cells
por: Shah, Disheet, et al.
Publicado: (2020)

The Junctophilin-2 Mutation p.(Thr161Lys) Is Associated with Hypertrophic Cardiomyopathy Using Patient-Specific iPS Cardiomyocytes and Demonstrates Prolonged Action Potential and Increased Arrhythmogenicity
por: Valtonen, Joona, et al.
Publicado: (2023)

Divergent effects of adrenaline in human induced pluripotent stem cell-derived cardiomyocytes obtained from hypertrophic cardiomyopathy
por: Prajapati, Chandra, et al.
Publicado: (2018)

Sex differences in heart: from basics to clinics
por: Prajapati, Chandra, et al.
Publicado: (2022)

Culture Conditions Affect Cardiac Differentiation Potential of Human Pluripotent Stem Cells
por: Ojala, Marisa, et al.
Publicado: (2012)

The Effect of Human and Mouse Fibroblast Feeder Cells on Cardiac Differentiation of Human Pluripotent Stem Cells
por: Pekkanen-Mattila, Mari, et al.
Publicado: (2012)

Simultaneous recordings of action potentials and calcium transients from human induced pluripotent stem cell derived cardiomyocytes
por: Prajapati, Chandra, et al.
Publicado: (2018)

Mutation-Specific Phenotypes in hiPSC-Derived Cardiomyocytes Carrying Either Myosin-Binding Protein C Or α-Tropomyosin Mutation for Hypertrophic Cardiomyopathy
por: Ojala, Marisa, et al.
Publicado: (2016)

Cardiomyocyte MEA Data Analysis (CardioMDA) – A Novel Field Potential Data Analysis Software for Pluripotent Stem Cell Derived Cardiomyocytes
por: Pradhapan, Paruthi, et al.
Publicado: (2013)

Video image-based analysis of single human induced pluripotent stem cell derived cardiomyocyte beating dynamics using digital image correlation
por: Ahola, Antti, et al.
Publicado: (2014)

M1‐linked ubiquitination facilitates NF‐κB activation and survival during sterile inflammation
por: Aalto, Anna, et al.
Publicado: (2022)

Analysis of Drug Effects on iPSC Cardiomyocytes with Machine Learning
por: Juhola, Martti, et al.
Publicado: (2020)

Low extracellular potassium prolongs repolarization and evokes early afterdepolarization in human induced pluripotent stem cell-derived cardiomyocytes
por: Kuusela, Jukka, et al.
Publicado: (2017)

The Effects of Pharmacological Compounds on Beat Rate Variations in Human Long QT-Syndrome Cardiomyocytes
por: Kuusela, Jukka, et al.
Publicado: (2016)

Oxygen gradient generator to improve in vitro modeling of ischemic stroke
por: Santiago, João, et al.
Publicado: (2023)

CytoSpectre: a tool for spectral analysis of oriented structures on cellular and subcellular levels
por: Kartasalo, Kimmo, et al.
Publicado: (2015)

Effects of cardioactive drugs on human induced pluripotent stem cell derived long QT syndrome cardiomyocytes
por: Kuusela, Jukka, et al.
Publicado: (2016)

Co-stimulation with IL-1β and TNF-α induces an inflammatory reactive astrocyte phenotype with neurosupportive characteristics in a human pluripotent stem cell model system
por: Hyvärinen, Tanja, et al.
Publicado: (2019)

Transportable system enabling multiple irradiation studies under simultaneous hypoxia in vitro
por: Metsälä, Olli, et al.
Publicado: (2018)

Novel Analysis Software for Detecting and Classifying Ca(2+) Transient Abnormalities in Stem Cell-Derived Cardiomyocytes
por: Penttinen, Kirsi, et al.
Publicado: (2015)

Obtaining Consent for Future Research with Induced Pluripotent Cells: Opportunities and Challenges
por: Aalto-Setälä, Katriina, et al.
Publicado: (2009)

2D and 3D Self-Assembling Nanofiber Hydrogels for Cardiomyocyte Culture
por: Ikonen, Liisa, et al.
Publicado: (2013)

Automatic Optimization of an in Silico Model of Human iPSC Derived Cardiomyocytes Recapitulating Calcium Handling Abnormalities
por: Paci, Michelangelo, et al.
Publicado: (2018)

Error-Correcting Output Codes in Classification of Human Induced Pluripotent Stem Cell Colony Images
por: Joutsijoki, Henry, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_90sba63onv5ig5u042u16g1pta