The Role of N(6)-Methyladenosine in Inflammatory Diseases

N(6)-Methyladenosine (m(6)A) is the most abundant epigenetic RNA modification in eukaryotes, regulating RNA metabolism (export, stability, translation, and decay) in cells through changes in the activity of writers, erasers, and readers and ultimately affecting human life or disease processes. Infla...

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Autores principales: Xu, Haojun, Lin, Changjie, Yang, Jinghan, Chen, Xi, Chen, Yingyu, Chen, Jianguo, Guo, Aizhen, Hu, Changmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792239/
https://www.ncbi.nlm.nih.gov/pubmed/36578520
http://dx.doi.org/10.1155/2022/9744771
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author Xu, Haojun
Lin, Changjie
Yang, Jinghan
Chen, Xi
Chen, Yingyu
Chen, Jianguo
Guo, Aizhen
Hu, Changmin
author_facet Xu, Haojun
Lin, Changjie
Yang, Jinghan
Chen, Xi
Chen, Yingyu
Chen, Jianguo
Guo, Aizhen
Hu, Changmin
author_sort Xu, Haojun
collection PubMed
description N(6)-Methyladenosine (m(6)A) is the most abundant epigenetic RNA modification in eukaryotes, regulating RNA metabolism (export, stability, translation, and decay) in cells through changes in the activity of writers, erasers, and readers and ultimately affecting human life or disease processes. Inflammation is a response to infection and injury in various diseases and has therefore attracted significant attention. Currently, extensive evidence indicates that m(6)A plays an essential role in inflammation. In this review, we focus on the mechanisms of m(6)A in inflammatory autoimmune diseases, metabolic disorder, cardio-cerebrovascular diseases, cancer, and pathogen-induced inflammation, as well as its possible role as targets for clinical diagnosis and treatment.
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spelling pubmed-97922392022-12-27 The Role of N(6)-Methyladenosine in Inflammatory Diseases Xu, Haojun Lin, Changjie Yang, Jinghan Chen, Xi Chen, Yingyu Chen, Jianguo Guo, Aizhen Hu, Changmin Oxid Med Cell Longev Review Article N(6)-Methyladenosine (m(6)A) is the most abundant epigenetic RNA modification in eukaryotes, regulating RNA metabolism (export, stability, translation, and decay) in cells through changes in the activity of writers, erasers, and readers and ultimately affecting human life or disease processes. Inflammation is a response to infection and injury in various diseases and has therefore attracted significant attention. Currently, extensive evidence indicates that m(6)A plays an essential role in inflammation. In this review, we focus on the mechanisms of m(6)A in inflammatory autoimmune diseases, metabolic disorder, cardio-cerebrovascular diseases, cancer, and pathogen-induced inflammation, as well as its possible role as targets for clinical diagnosis and treatment. Hindawi 2022-12-12 /pmc/articles/PMC9792239/ /pubmed/36578520 http://dx.doi.org/10.1155/2022/9744771 Text en Copyright © 2022 Haojun Xu et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Xu, Haojun
Lin, Changjie
Yang, Jinghan
Chen, Xi
Chen, Yingyu
Chen, Jianguo
Guo, Aizhen
Hu, Changmin
The Role of N(6)-Methyladenosine in Inflammatory Diseases
title The Role of N(6)-Methyladenosine in Inflammatory Diseases
title_full The Role of N(6)-Methyladenosine in Inflammatory Diseases
title_fullStr The Role of N(6)-Methyladenosine in Inflammatory Diseases
title_full_unstemmed The Role of N(6)-Methyladenosine in Inflammatory Diseases
title_short The Role of N(6)-Methyladenosine in Inflammatory Diseases
title_sort role of n(6)-methyladenosine in inflammatory diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792239/
https://www.ncbi.nlm.nih.gov/pubmed/36578520
http://dx.doi.org/10.1155/2022/9744771
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