Cargando…
Relationship of Serum Zinc Levels with Cardiometabolic Traits in Overweight and Obese Schoolchildren from Mexico City
Zinc (Zn) participates as a cofactor for many enzymes in the cellular metabolism, and its serum levels have been associated with different metabolic diseases, especially obesity (OB). Nevertheless, its associations are not clear in the children population. The objective of this study is to evaluate...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792317/ https://www.ncbi.nlm.nih.gov/pubmed/36572827 http://dx.doi.org/10.1007/s12011-022-03533-8 |
_version_ | 1784859608330797056 |
---|---|
author | Martínez-Navarro, Israel Vilchis-Gil, Jenny Cossío-Torres, Patricia Elizabeth Hernández-Mendoza, Héctor Klünder-Klünder, Miguel Layseca-Espinosa, Esther Galicia-Cruz, Othir Gidalti Rios-Lugo, María Judith |
author_facet | Martínez-Navarro, Israel Vilchis-Gil, Jenny Cossío-Torres, Patricia Elizabeth Hernández-Mendoza, Héctor Klünder-Klünder, Miguel Layseca-Espinosa, Esther Galicia-Cruz, Othir Gidalti Rios-Lugo, María Judith |
author_sort | Martínez-Navarro, Israel |
collection | PubMed |
description | Zinc (Zn) participates as a cofactor for many enzymes in the cellular metabolism, and its serum levels have been associated with different metabolic diseases, especially obesity (OB). Nevertheless, its associations are not clear in the children population. The objective of this study is to evaluate the association between serum Zn levels (SZn) with overweight/obesity status (OW/OB), as well as its cardiometabolic traits in a population of children in Mexico City. Anthropometrical data (body mass index z score (BMIz)), demographic variables (age and sex), and cardiometabolic traits (total cholesterol (TC), high-density lipoprotein cholesterol (HDLc), low-density lipoprotein cholesterol (LDLc), triglycerides (TG), fasting plasma glucose (FPG), and insulin) were analyzed in this cross-sectional study. SZn were measured by inductively coupled plasma mass spectrometry (ICP–MS). The population included 210 children from Mexico City (girls (n = 105) and boys (n = 105)) between ages 6 and 10 years. Normal-weight (NW) schoolchildren had higher SZn concentrations (66 µg/dL; IQR: 48 to 91) compared to OW or OB schoolchildren (61 µg/dL; IQR: 45 to 76). The data showed a significant negative association between SZn and BMIz without sex exclusion (r = − 0.181 and p = 0.009). The boy’s population did not show an association between the SZn and BMIz compared to the girl’s population which showed a significant negative association (r = − 0.277 and p = 0.004). In addition, other associations were found between SZn and TC (boys (r = 0.214 and p = 0.025), LDLc (boys (r = 0.213 and p = 0.029), and TG (girls (r = − 0.260 and p = 0.007)). Moreover, 38.6% of the total children in our population study had Zn deficiency (ZnD). NW schoolchildren had higher SZn concentrations compared to OW or OB schoolchildren. A diet low in Zn can be a factor to evaluate in the development of childhood OB in Mexico. However, further studies need to be performed on the children Mexican population to replicate and confirm our findings. |
format | Online Article Text |
id | pubmed-9792317 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-97923172022-12-27 Relationship of Serum Zinc Levels with Cardiometabolic Traits in Overweight and Obese Schoolchildren from Mexico City Martínez-Navarro, Israel Vilchis-Gil, Jenny Cossío-Torres, Patricia Elizabeth Hernández-Mendoza, Héctor Klünder-Klünder, Miguel Layseca-Espinosa, Esther Galicia-Cruz, Othir Gidalti Rios-Lugo, María Judith Biol Trace Elem Res Article Zinc (Zn) participates as a cofactor for many enzymes in the cellular metabolism, and its serum levels have been associated with different metabolic diseases, especially obesity (OB). Nevertheless, its associations are not clear in the children population. The objective of this study is to evaluate the association between serum Zn levels (SZn) with overweight/obesity status (OW/OB), as well as its cardiometabolic traits in a population of children in Mexico City. Anthropometrical data (body mass index z score (BMIz)), demographic variables (age and sex), and cardiometabolic traits (total cholesterol (TC), high-density lipoprotein cholesterol (HDLc), low-density lipoprotein cholesterol (LDLc), triglycerides (TG), fasting plasma glucose (FPG), and insulin) were analyzed in this cross-sectional study. SZn were measured by inductively coupled plasma mass spectrometry (ICP–MS). The population included 210 children from Mexico City (girls (n = 105) and boys (n = 105)) between ages 6 and 10 years. Normal-weight (NW) schoolchildren had higher SZn concentrations (66 µg/dL; IQR: 48 to 91) compared to OW or OB schoolchildren (61 µg/dL; IQR: 45 to 76). The data showed a significant negative association between SZn and BMIz without sex exclusion (r = − 0.181 and p = 0.009). The boy’s population did not show an association between the SZn and BMIz compared to the girl’s population which showed a significant negative association (r = − 0.277 and p = 0.004). In addition, other associations were found between SZn and TC (boys (r = 0.214 and p = 0.025), LDLc (boys (r = 0.213 and p = 0.029), and TG (girls (r = − 0.260 and p = 0.007)). Moreover, 38.6% of the total children in our population study had Zn deficiency (ZnD). NW schoolchildren had higher SZn concentrations compared to OW or OB schoolchildren. A diet low in Zn can be a factor to evaluate in the development of childhood OB in Mexico. However, further studies need to be performed on the children Mexican population to replicate and confirm our findings. Springer US 2022-12-27 /pmc/articles/PMC9792317/ /pubmed/36572827 http://dx.doi.org/10.1007/s12011-022-03533-8 Text en © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Article Martínez-Navarro, Israel Vilchis-Gil, Jenny Cossío-Torres, Patricia Elizabeth Hernández-Mendoza, Héctor Klünder-Klünder, Miguel Layseca-Espinosa, Esther Galicia-Cruz, Othir Gidalti Rios-Lugo, María Judith Relationship of Serum Zinc Levels with Cardiometabolic Traits in Overweight and Obese Schoolchildren from Mexico City |
title | Relationship of Serum Zinc Levels with Cardiometabolic Traits in Overweight and Obese Schoolchildren from Mexico City |
title_full | Relationship of Serum Zinc Levels with Cardiometabolic Traits in Overweight and Obese Schoolchildren from Mexico City |
title_fullStr | Relationship of Serum Zinc Levels with Cardiometabolic Traits in Overweight and Obese Schoolchildren from Mexico City |
title_full_unstemmed | Relationship of Serum Zinc Levels with Cardiometabolic Traits in Overweight and Obese Schoolchildren from Mexico City |
title_short | Relationship of Serum Zinc Levels with Cardiometabolic Traits in Overweight and Obese Schoolchildren from Mexico City |
title_sort | relationship of serum zinc levels with cardiometabolic traits in overweight and obese schoolchildren from mexico city |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792317/ https://www.ncbi.nlm.nih.gov/pubmed/36572827 http://dx.doi.org/10.1007/s12011-022-03533-8 |
work_keys_str_mv | AT martineznavarroisrael relationshipofserumzinclevelswithcardiometabolictraitsinoverweightandobeseschoolchildrenfrommexicocity AT vilchisgiljenny relationshipofserumzinclevelswithcardiometabolictraitsinoverweightandobeseschoolchildrenfrommexicocity AT cossiotorrespatriciaelizabeth relationshipofserumzinclevelswithcardiometabolictraitsinoverweightandobeseschoolchildrenfrommexicocity AT hernandezmendozahector relationshipofserumzinclevelswithcardiometabolictraitsinoverweightandobeseschoolchildrenfrommexicocity AT klunderklundermiguel relationshipofserumzinclevelswithcardiometabolictraitsinoverweightandobeseschoolchildrenfrommexicocity AT laysecaespinosaesther relationshipofserumzinclevelswithcardiometabolictraitsinoverweightandobeseschoolchildrenfrommexicocity AT galiciacruzothirgidalti relationshipofserumzinclevelswithcardiometabolictraitsinoverweightandobeseschoolchildrenfrommexicocity AT rioslugomariajudith relationshipofserumzinclevelswithcardiometabolictraitsinoverweightandobeseschoolchildrenfrommexicocity |