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Blood specimen rejection rate in clinical laboratory: A systematic review and meta-analysis

BACKGROUND: Clinical laboratory errors have a great impact on patient safety and treatment. Although specimen rejections result in longer turnaround times and increased health-care costs, different studies present inconsistent findings. Therefore, the study aimed to determine the pooled prevalence o...

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Autores principales: Getawa, Solomon, Aynalem, Melak, Melku, Mulugeta, Adane, Tiruneh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792348/
https://www.ncbi.nlm.nih.gov/pubmed/36582816
http://dx.doi.org/10.1016/j.plabm.2022.e00303
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author Getawa, Solomon
Aynalem, Melak
Melku, Mulugeta
Adane, Tiruneh
author_facet Getawa, Solomon
Aynalem, Melak
Melku, Mulugeta
Adane, Tiruneh
author_sort Getawa, Solomon
collection PubMed
description BACKGROUND: Clinical laboratory errors have a great impact on patient safety and treatment. Although specimen rejections result in longer turnaround times and increased health-care costs, different studies present inconsistent findings. Therefore, the study aimed to determine the pooled prevalence of blood specimen rejection in clinical laboratory. METHODS: Electronic databases including MEDLINE, PubMed, EMBASE, HINARI, Cochrane Library, Google Scholar, and Science Direct were comprehensively searched. Articles were screened and the data extracted independently by authors. Publication bias was checked by funnel-plots and Egger's statistical test. Pooled prevalence was estimated using a random-effects model. The I(2) statistical test were performed to assess heterogeneity. The possible sources of heterogeneity were analyzed through subgroup and sensitivity analysis. RESULTS: Total of 26 articles with 16,118,499 blood sample requests were included in the meta-analysis. The pooled prevalence of blood specimen rejection in the clinical laboratory was 1.99% (95% CI: 1.73, 2.25). Subgroup analysis showed that, the highest prevalence of specimen rejection was observed in Asia [2.82% (95%CI: 2.21, 3.43)] and lowest in America [0.55% (95%CI: 0.27, 0.82)]. The leading cause of blood specimen rejection in clinical laboratories were clotted specimen (32.23% (95%CI: 21.02, 43.43)), hemolysis (22.87% (95%CI: 16.72, 29.02)), insufficient volume (22.81% (95%CI: 16.75, 28.87)), and labelling errors (7.31% (95%CI: 6.12, 8.58)). CONCLUSION: The pooled prevalence of blood specimen rejection rate is relatively high especially in developing regions. Therefore, proper training for specimen collectors, compliance with good laboratory practices specific to specimen collection, transportation, and preparation is required to reduce the rejection rate.
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spelling pubmed-97923482022-12-28 Blood specimen rejection rate in clinical laboratory: A systematic review and meta-analysis Getawa, Solomon Aynalem, Melak Melku, Mulugeta Adane, Tiruneh Pract Lab Med Review Article BACKGROUND: Clinical laboratory errors have a great impact on patient safety and treatment. Although specimen rejections result in longer turnaround times and increased health-care costs, different studies present inconsistent findings. Therefore, the study aimed to determine the pooled prevalence of blood specimen rejection in clinical laboratory. METHODS: Electronic databases including MEDLINE, PubMed, EMBASE, HINARI, Cochrane Library, Google Scholar, and Science Direct were comprehensively searched. Articles were screened and the data extracted independently by authors. Publication bias was checked by funnel-plots and Egger's statistical test. Pooled prevalence was estimated using a random-effects model. The I(2) statistical test were performed to assess heterogeneity. The possible sources of heterogeneity were analyzed through subgroup and sensitivity analysis. RESULTS: Total of 26 articles with 16,118,499 blood sample requests were included in the meta-analysis. The pooled prevalence of blood specimen rejection in the clinical laboratory was 1.99% (95% CI: 1.73, 2.25). Subgroup analysis showed that, the highest prevalence of specimen rejection was observed in Asia [2.82% (95%CI: 2.21, 3.43)] and lowest in America [0.55% (95%CI: 0.27, 0.82)]. The leading cause of blood specimen rejection in clinical laboratories were clotted specimen (32.23% (95%CI: 21.02, 43.43)), hemolysis (22.87% (95%CI: 16.72, 29.02)), insufficient volume (22.81% (95%CI: 16.75, 28.87)), and labelling errors (7.31% (95%CI: 6.12, 8.58)). CONCLUSION: The pooled prevalence of blood specimen rejection rate is relatively high especially in developing regions. Therefore, proper training for specimen collectors, compliance with good laboratory practices specific to specimen collection, transportation, and preparation is required to reduce the rejection rate. Elsevier 2022-12-19 /pmc/articles/PMC9792348/ /pubmed/36582816 http://dx.doi.org/10.1016/j.plabm.2022.e00303 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Getawa, Solomon
Aynalem, Melak
Melku, Mulugeta
Adane, Tiruneh
Blood specimen rejection rate in clinical laboratory: A systematic review and meta-analysis
title Blood specimen rejection rate in clinical laboratory: A systematic review and meta-analysis
title_full Blood specimen rejection rate in clinical laboratory: A systematic review and meta-analysis
title_fullStr Blood specimen rejection rate in clinical laboratory: A systematic review and meta-analysis
title_full_unstemmed Blood specimen rejection rate in clinical laboratory: A systematic review and meta-analysis
title_short Blood specimen rejection rate in clinical laboratory: A systematic review and meta-analysis
title_sort blood specimen rejection rate in clinical laboratory: a systematic review and meta-analysis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792348/
https://www.ncbi.nlm.nih.gov/pubmed/36582816
http://dx.doi.org/10.1016/j.plabm.2022.e00303
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