Substantial uneven proliferation of CD4(+) T cells during recovery from acute HIV infection is sufficient to explain the observed expanded clones in the HIV reservoir

The HIV reservoir is a population of 1–10 million anatomically dispersed, latently infected memory CD4(+) T cells in which HIV DNA is quiescently integrated into human chromosomal DNA. When antiretroviral therapy (ART) is stopped and HIV replication initiates in one of these cells, systemic viral sp...

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Detalles Bibliográficos
Autores principales: Tettamanti Boshier, Florencia A., Reeves, Daniel B., Duke, Elizabeth R., Swan, David A., Prlic, Martin, Cardozo-Ojeda, E. Fabian, Schiffer, Joshua T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792356/
https://www.ncbi.nlm.nih.gov/pubmed/36582473
http://dx.doi.org/10.1016/j.jve.2022.100091

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