Loss of tumor suppressor WWOX accelerates pancreatic cancer development through promotion of TGFβ/BMP2 signaling

Pancreatic cancer is one of the most lethal cancers, owing to its late diagnosis and resistance to chemotherapy. The tumor suppressor WW domain-containing oxidoreductase (WWOX), one of the most active fragile sites in the human genome (FRA16D), is commonly altered in pancreatic cancer. However, the...

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Detalles Bibliográficos
Autores principales: Husanie, Hussam, Abu-Remaileh, Muhannad, Maroun, Kian, Abu-Tair, Lina, Safadi, Hazem, Atlan, Karine, Golan, Talia, Aqeilan, Rami I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792466/
https://www.ncbi.nlm.nih.gov/pubmed/36572673
http://dx.doi.org/10.1038/s41419-022-05519-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792466/
https://www.ncbi.nlm.nih.gov/pubmed/36572673
http://dx.doi.org/10.1038/s41419-022-05519-9

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