Pharmacological inhibition of Lin28 promotes ketogenesis and restores lipid homeostasis in models of non-alcoholic fatty liver disease

Lin28 RNA-binding proteins are stem-cell factors that play key roles in development. Lin28 suppresses the biogenesis of let-7 microRNAs and regulates mRNA translation. Notably, let-7 inhibits Lin28, establishing a double-negative feedback loop. The Lin28/let-7 axis resides at the interface of metabo...

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Detalles Bibliográficos
Autores principales: Lekka, Evangelia, Kokanovic, Aleksandra, Mosole, Simone, Civenni, Gianluca, Schmidli, Sandro, Laski, Artur, Ghidini, Alice, Iyer, Pavithra, Berk, Christian, Behera, Alok, Catapano, Carlo V., Hall, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792516/
https://www.ncbi.nlm.nih.gov/pubmed/36572670
http://dx.doi.org/10.1038/s41467-022-35481-1

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