Implantable niche with local immunosuppression for islet allotransplantation achieves type 1 diabetes reversal in rats

Pancreatic islet transplantation efficacy for type 1 diabetes (T1D) management is limited by hypoxia-related graft attrition and need for systemic immunosuppression. To overcome these challenges, we developed the Neovascularized Implantable Cell Homing and Encapsulation (NICHE) device, which integra...

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Detalles Bibliográficos
Autores principales: Paez-Mayorga, Jesus, Campa-Carranza, Jocelyn Nikita, Capuani, Simone, Hernandez, Nathanael, Liu, Hsuan-Chen, Chua, Corrine Ying Xuan, Pons-Faudoa, Fernanda Paola, Malgir, Gulsah, Alvarez, Bella, Niles, Jean A., Argueta, Lissenya B., Shelton, Kathryn A., Kezar, Sarah, Nehete, Pramod N., Berman, Dora M., Willman, Melissa A., Li, Xian C., Ricordi, Camillo, Nichols, Joan E., Gaber, A. Osama, Kenyon, Norma S., Grattoni, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792517/
https://www.ncbi.nlm.nih.gov/pubmed/36572684
http://dx.doi.org/10.1038/s41467-022-35629-z

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