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Fecal level of butyric acid, a microbiome-derived metabolite, is increased in patients with severe carotid atherosclerosis
The short-chain fatty acid (SCFA) butyric acid maintains a healthy gut barrier and vascular endothelium. We aimed to investigate the association between fecal butyric acid, carotid atherosclerosis and risk factors for ischemic stroke. Patients with severe carotid atherosclerosis (i.e. ≥ 50% stenosis...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792531/ https://www.ncbi.nlm.nih.gov/pubmed/36572703 http://dx.doi.org/10.1038/s41598-022-26759-x |
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author | Stø, Kristine Valeur, Jørgen Ueland, Thor Malmstrøm, Gunn Helen Bjerkeli, Vigdis Trøseid, Marius Hov, Johannes R. Holm, Kristian Vestad, Beate Halvorsen, Bente Skjelland, Mona Skagen, Karolina R. |
author_facet | Stø, Kristine Valeur, Jørgen Ueland, Thor Malmstrøm, Gunn Helen Bjerkeli, Vigdis Trøseid, Marius Hov, Johannes R. Holm, Kristian Vestad, Beate Halvorsen, Bente Skjelland, Mona Skagen, Karolina R. |
author_sort | Stø, Kristine |
collection | PubMed |
description | The short-chain fatty acid (SCFA) butyric acid maintains a healthy gut barrier and vascular endothelium. We aimed to investigate the association between fecal butyric acid, carotid atherosclerosis and risk factors for ischemic stroke. Patients with severe carotid atherosclerosis (i.e. ≥ 50% stenosis) (n = 43) were compared with healthy controls (n = 38). We analyzed fecal SCFAs by gas chromatography, microbiota composition by 16S rRNA sequencing, markers of gut barrier damage and inflammasome activation by immunoassay, and plasma SCFAs by ultra-high performance liquid chromatography-tandem mass spectroscopy. Patients had higher fecal butyric acid level (p = 0.024), along with increased functional potential of microbial butyric acid production (p = 0.031), compared with controls. Dietary fiber intake was comparable. Patients had higher levels of gut barrier damage markers CCL25 and IFABP, and the inflammasome activation marker IL-18, whereas plasma level of butyric was similar. Increased fecal butyric acid was associated with higher BMI, waist-hip ratio, HbA1c, CRP and leukocyte count. Contrary to our hypothesis, patients with severe carotid atherosclerosis had higher fecal butyric acid level, and increased microbial production, compared with controls. Gut barrier damage in patients might indicate decreased absorption of butyric acid and hence contribute to the higher fecal level. |
format | Online Article Text |
id | pubmed-9792531 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-97925312022-12-28 Fecal level of butyric acid, a microbiome-derived metabolite, is increased in patients with severe carotid atherosclerosis Stø, Kristine Valeur, Jørgen Ueland, Thor Malmstrøm, Gunn Helen Bjerkeli, Vigdis Trøseid, Marius Hov, Johannes R. Holm, Kristian Vestad, Beate Halvorsen, Bente Skjelland, Mona Skagen, Karolina R. Sci Rep Article The short-chain fatty acid (SCFA) butyric acid maintains a healthy gut barrier and vascular endothelium. We aimed to investigate the association between fecal butyric acid, carotid atherosclerosis and risk factors for ischemic stroke. Patients with severe carotid atherosclerosis (i.e. ≥ 50% stenosis) (n = 43) were compared with healthy controls (n = 38). We analyzed fecal SCFAs by gas chromatography, microbiota composition by 16S rRNA sequencing, markers of gut barrier damage and inflammasome activation by immunoassay, and plasma SCFAs by ultra-high performance liquid chromatography-tandem mass spectroscopy. Patients had higher fecal butyric acid level (p = 0.024), along with increased functional potential of microbial butyric acid production (p = 0.031), compared with controls. Dietary fiber intake was comparable. Patients had higher levels of gut barrier damage markers CCL25 and IFABP, and the inflammasome activation marker IL-18, whereas plasma level of butyric was similar. Increased fecal butyric acid was associated with higher BMI, waist-hip ratio, HbA1c, CRP and leukocyte count. Contrary to our hypothesis, patients with severe carotid atherosclerosis had higher fecal butyric acid level, and increased microbial production, compared with controls. Gut barrier damage in patients might indicate decreased absorption of butyric acid and hence contribute to the higher fecal level. Nature Publishing Group UK 2022-12-26 /pmc/articles/PMC9792531/ /pubmed/36572703 http://dx.doi.org/10.1038/s41598-022-26759-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Stø, Kristine Valeur, Jørgen Ueland, Thor Malmstrøm, Gunn Helen Bjerkeli, Vigdis Trøseid, Marius Hov, Johannes R. Holm, Kristian Vestad, Beate Halvorsen, Bente Skjelland, Mona Skagen, Karolina R. Fecal level of butyric acid, a microbiome-derived metabolite, is increased in patients with severe carotid atherosclerosis |
title | Fecal level of butyric acid, a microbiome-derived metabolite, is increased in patients with severe carotid atherosclerosis |
title_full | Fecal level of butyric acid, a microbiome-derived metabolite, is increased in patients with severe carotid atherosclerosis |
title_fullStr | Fecal level of butyric acid, a microbiome-derived metabolite, is increased in patients with severe carotid atherosclerosis |
title_full_unstemmed | Fecal level of butyric acid, a microbiome-derived metabolite, is increased in patients with severe carotid atherosclerosis |
title_short | Fecal level of butyric acid, a microbiome-derived metabolite, is increased in patients with severe carotid atherosclerosis |
title_sort | fecal level of butyric acid, a microbiome-derived metabolite, is increased in patients with severe carotid atherosclerosis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792531/ https://www.ncbi.nlm.nih.gov/pubmed/36572703 http://dx.doi.org/10.1038/s41598-022-26759-x |
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