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Biosynthesis of prostaglandin 15dPGJ(2) -glutathione and 15dPGJ(2)-cysteine conjugates in macrophages and mast cells via MGST3

Inhibition of microsomal prostaglandin E synthase-1 (mPGES-1) results in decreased production of proinflammatory PGE(2) and can lead to shunting of PGH(2) into the prostaglandin D(2) (PGD(2))/15-deoxy-Δ(12,14)-prostaglandin J(2) (15dPGJ(2)) pathway. 15dPGJ(2) forms Michael adducts with thiol-contain...

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Detalles Bibliográficos
Autores principales:	Steinmetz-Späh, Julia, Liu, Jianyang, Singh, Rajkumar, Ekoff, Maria, Boddul, Sanjaykumar, Tang, Xiao, Bergqvist, Filip, Idborg, Helena, Heitel, Pascal, Rönnberg, Elin, Merk, Daniel, Wermeling, Fredrik, Haeggström, Jesper Z., Nilsson, Gunnar, Steinhilber, Dieter, Larsson, Karin, Korotkova, Marina, Jakobsson, Per-Johan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792570/ https://www.ncbi.nlm.nih.gov/pubmed/36370807 http://dx.doi.org/10.1016/j.jlr.2022.100310

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