Hepatocyte-specific TMEM16A deficiency alleviates hepatic ischemia/reperfusion injury via suppressing GPX4-mediated ferroptosis

Ischemia/reperfusion (I/R)-induced liver injury with severe cell death is a major complication of liver transplantation. Transmembrane member 16A (TMEM16A), a component of hepatocyte Ca(2+)-activated chloride channel, has been implicated in a variety of liver diseases. However, its role in hepatic I...

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Detalles Bibliográficos
Autores principales: Guo, Jiawei, Song, Zihao, Yu, Jie, Li, Chengyi, Jin, Chenchen, Duan, Wei, Liu, Xiu, Liu, Yingying, Huang, Shuai, Tuo, Yonghua, Pei, Fei, Jian, Zhengyang, Zhou, Pengyu, Zheng, Shaoyi, Zou, Zhaowei, Zhang, Feng, Gong, Quan, Liang, Sijia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792590/
https://www.ncbi.nlm.nih.gov/pubmed/36572666
http://dx.doi.org/10.1038/s41419-022-05518-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792590/
https://www.ncbi.nlm.nih.gov/pubmed/36572666
http://dx.doi.org/10.1038/s41419-022-05518-w

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