Adjunctive granisetron therapy in patients with sepsis or septic shock (GRANTISS): A single-center, single-blinded, randomized, controlled clinical trial

Background: In preclinical experiments, we demonstrated that the 5-HT3 receptor antagonist granisetron results in reduced inflammation and improved survival in septic mice. This randomized controlled trial was designed to assess the efficacy and safety of granisetron in patients with sepsis. Methods...

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Detalles Bibliográficos
Autores principales: Guan, Jianbin, Liao, Yuping, Guo, Yuexun, Yu, Shuang, Wei, Rongjuan, Niu, Mengwei, Gan, Jianwei, Zhang, Lu, Li, Tong, Lv, Jin, Shichen, Maoyou, Chang, Ping, Chen, Peng, Liu, Zhanguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792607/
https://www.ncbi.nlm.nih.gov/pubmed/36582527
http://dx.doi.org/10.3389/fphar.2022.1013284

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