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Identification and drug metabolic characterization of four new CYP2C9 variants CYP2C972-75 in the Chinese Han population

Cytochrome 2C9 (CYP2C9), one of the most important drug metabolic enzymes in the human hepatic P450 superfamily, is required for the metabolism of 15% of clinical drugs. Similar to other CYP2C family members, CYP2C9 gene has a high genetic polymorphism which can cause significant racial and inter-in...

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Detalles Bibliográficos
Autores principales:	Zhao, Fang-Ling, Zhang, Qing, Wang, Shuang-Hu, Hong, Yun, Zhou, Shan, Zhou, Quan, Geng, Pei-Wu, Luo, Qing-Feng, Yang, Jie-Fu, Chen, Hao, Cai, Jian-Ping, Dai, Da-Peng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792615/ https://www.ncbi.nlm.nih.gov/pubmed/36582532 http://dx.doi.org/10.3389/fphar.2022.1007268

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