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Case report: Exploring under the tip of the iceberg: A case series of “self-limiting” multisystem inflammatory syndrome in children

Multisystem inflammatory syndrome in children (MIS-C) is a serious condition triggered by SARS-COV-2 infection, characterized by persistent fever, multiorgan dysfunction, and increased inflammatory markers. It requires hospitalization and prompt treatment, with nearly 60% of the cases needing intens...

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Autores principales: Meneghel, Alessandra, Martini, Giorgia, Balzarin, Marta, Zabadneh, Nadia, Fastiggi, Michele, Tirelli, Francesca, Zulian, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792681/
https://www.ncbi.nlm.nih.gov/pubmed/36582511
http://dx.doi.org/10.3389/fped.2022.1012582
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author Meneghel, Alessandra
Martini, Giorgia
Balzarin, Marta
Zabadneh, Nadia
Fastiggi, Michele
Tirelli, Francesca
Zulian, Francesco
author_facet Meneghel, Alessandra
Martini, Giorgia
Balzarin, Marta
Zabadneh, Nadia
Fastiggi, Michele
Tirelli, Francesca
Zulian, Francesco
author_sort Meneghel, Alessandra
collection PubMed
description Multisystem inflammatory syndrome in children (MIS-C) is a serious condition triggered by SARS-COV-2 infection, characterized by persistent fever, multiorgan dysfunction, and increased inflammatory markers. It requires hospitalization and prompt treatment, with nearly 60% of the cases needing intensive care and 2% fatality rate. A wide spectrum of clinical characteristics and therapeutic approaches has been reported in MIS-C. We describe a series of four patients with MIS-C, defined according to the current case definitions, with a self-limiting course and no need for immunomodulatory treatment (“self-limiting MIS-C”). Few data about self-limiting MIS-C are available to date and no information on medium- and long-term outcome of this subset of patients has been reported. Although limited in size, our experience provides new insights into the MIS-C syndrome, highlighting an underestimated aspect of the disease that may have significant therapeutic implications.
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spelling pubmed-97926812022-12-28 Case report: Exploring under the tip of the iceberg: A case series of “self-limiting” multisystem inflammatory syndrome in children Meneghel, Alessandra Martini, Giorgia Balzarin, Marta Zabadneh, Nadia Fastiggi, Michele Tirelli, Francesca Zulian, Francesco Front Pediatr Pediatrics Multisystem inflammatory syndrome in children (MIS-C) is a serious condition triggered by SARS-COV-2 infection, characterized by persistent fever, multiorgan dysfunction, and increased inflammatory markers. It requires hospitalization and prompt treatment, with nearly 60% of the cases needing intensive care and 2% fatality rate. A wide spectrum of clinical characteristics and therapeutic approaches has been reported in MIS-C. We describe a series of four patients with MIS-C, defined according to the current case definitions, with a self-limiting course and no need for immunomodulatory treatment (“self-limiting MIS-C”). Few data about self-limiting MIS-C are available to date and no information on medium- and long-term outcome of this subset of patients has been reported. Although limited in size, our experience provides new insights into the MIS-C syndrome, highlighting an underestimated aspect of the disease that may have significant therapeutic implications. Frontiers Media S.A. 2022-12-13 /pmc/articles/PMC9792681/ /pubmed/36582511 http://dx.doi.org/10.3389/fped.2022.1012582 Text en © 2022 Meneghel, Martini, Balzarin, Zabadneh, Fastiggi, Tirelli and Zulian. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Meneghel, Alessandra
Martini, Giorgia
Balzarin, Marta
Zabadneh, Nadia
Fastiggi, Michele
Tirelli, Francesca
Zulian, Francesco
Case report: Exploring under the tip of the iceberg: A case series of “self-limiting” multisystem inflammatory syndrome in children
title Case report: Exploring under the tip of the iceberg: A case series of “self-limiting” multisystem inflammatory syndrome in children
title_full Case report: Exploring under the tip of the iceberg: A case series of “self-limiting” multisystem inflammatory syndrome in children
title_fullStr Case report: Exploring under the tip of the iceberg: A case series of “self-limiting” multisystem inflammatory syndrome in children
title_full_unstemmed Case report: Exploring under the tip of the iceberg: A case series of “self-limiting” multisystem inflammatory syndrome in children
title_short Case report: Exploring under the tip of the iceberg: A case series of “self-limiting” multisystem inflammatory syndrome in children
title_sort case report: exploring under the tip of the iceberg: a case series of “self-limiting” multisystem inflammatory syndrome in children
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792681/
https://www.ncbi.nlm.nih.gov/pubmed/36582511
http://dx.doi.org/10.3389/fped.2022.1012582
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