Excessive gluconeogenesis causes the hepatic insulin resistance paradox and its sequelae

BACKGROUND: Hepatic insulin signaling suppresses gluconeogenesis but promotes de novo lipid synthesis. Paradoxically, hepatic insulin resistance (HIR) enhances both gluconeogenesis and de novo lipid synthesis. Elucidation of the etiology of this paradox, which participates in the pathogenesis of non...

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Detalles Bibliográficos
Autor principal: Onyango, Arnold N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792795/
https://www.ncbi.nlm.nih.gov/pubmed/36582692
http://dx.doi.org/10.1016/j.heliyon.2022.e12294

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792795/
https://www.ncbi.nlm.nih.gov/pubmed/36582692
http://dx.doi.org/10.1016/j.heliyon.2022.e12294

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