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Excessive gluconeogenesis causes the hepatic insulin resistance paradox and its sequelae
BACKGROUND: Hepatic insulin signaling suppresses gluconeogenesis but promotes de novo lipid synthesis. Paradoxically, hepatic insulin resistance (HIR) enhances both gluconeogenesis and de novo lipid synthesis. Elucidation of the etiology of this paradox, which participates in the pathogenesis of non...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Elsevier
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792795/ https://www.ncbi.nlm.nih.gov/pubmed/36582692 http://dx.doi.org/10.1016/j.heliyon.2022.e12294 |