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AB010. Clinical significance of serum Cyfra 21-1 as a marker in thymic epithelial tumors

BACKGROUND: There have been no specific serum biomarkers for thymic epithelial tumors (TETs) yet. The study aimed to explore the diagnostic and prognostic value of potentially relevant serum tumor markers in TETs. METHODS: We retrospectively analyzed the database of our own with the aim of reviewing...

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Autores principales: Hao, Xiuxiu, Zhang, Xuefei, Fang, Wentao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792826/
http://dx.doi.org/10.21037/med-22-ab010
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author Hao, Xiuxiu
Zhang, Xuefei
Fang, Wentao
author_facet Hao, Xiuxiu
Zhang, Xuefei
Fang, Wentao
author_sort Hao, Xiuxiu
collection PubMed
description BACKGROUND: There have been no specific serum biomarkers for thymic epithelial tumors (TETs) yet. The study aimed to explore the diagnostic and prognostic value of potentially relevant serum tumor markers in TETs. METHODS: We retrospectively analyzed the database of our own with the aim of reviewing the clinical records of 301 patients who have a thymic epithelial tumor after radical thymectomy, in the period between November 2012 and December 2017. Logistic regression analysis was used to evaluate relationships between tumor markers and tumor characteristics. Cox regression analysis and Kaplan Meier analysis were used to evaluate free-from-recurrence (FFR) in complete resected (R0) patients. RESULTS: There were 231 (76.7%) thymoma patients, 70 (23.3%) thymic carcinomas (TCs) and neuroendocrine thymic tumors (NETTs) patients in the study. The carcinoembryonic antigen (CEA), Cyfra 21-1, squamous cell carcinoma (SCC) antigen, neuron-specific enolase (NSE), and cancer antigen 125 (CA125) levels were evaluated. Elevated Cyfra 21-1, older age, higher T stage, and N stage were associated with TCs and NETTs in multivariable logistic regression analysis. In 222 patients who received R0 resection without neoadjuvant therapy, elevated Cyfra 21-1, higher T stage, and TCs and NETTs were associated with a poorer 5-year FFR in Cox regression analysis. There were significant differences in 5-year FFR between an elevated Cyfra 21-1 level and a normal Cyfra 21-1 level (42.9% vs. 92.4%, P<0.001). As for histological subtypes, TCs and NETTs were associated with a poorer 5-year FFR than thymomas (59.8% vs. 95.0%, P<0.001). CONCLUSIONS: Serum Cyfra 21-1 level could be a potential tumor marker in the diagnosis of thymic carcinomas and NETTs, and the prognosis of recurrence.
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spelling pubmed-97928262022-12-30 AB010. Clinical significance of serum Cyfra 21-1 as a marker in thymic epithelial tumors Hao, Xiuxiu Zhang, Xuefei Fang, Wentao Mediastinum Abstract BACKGROUND: There have been no specific serum biomarkers for thymic epithelial tumors (TETs) yet. The study aimed to explore the diagnostic and prognostic value of potentially relevant serum tumor markers in TETs. METHODS: We retrospectively analyzed the database of our own with the aim of reviewing the clinical records of 301 patients who have a thymic epithelial tumor after radical thymectomy, in the period between November 2012 and December 2017. Logistic regression analysis was used to evaluate relationships between tumor markers and tumor characteristics. Cox regression analysis and Kaplan Meier analysis were used to evaluate free-from-recurrence (FFR) in complete resected (R0) patients. RESULTS: There were 231 (76.7%) thymoma patients, 70 (23.3%) thymic carcinomas (TCs) and neuroendocrine thymic tumors (NETTs) patients in the study. The carcinoembryonic antigen (CEA), Cyfra 21-1, squamous cell carcinoma (SCC) antigen, neuron-specific enolase (NSE), and cancer antigen 125 (CA125) levels were evaluated. Elevated Cyfra 21-1, older age, higher T stage, and N stage were associated with TCs and NETTs in multivariable logistic regression analysis. In 222 patients who received R0 resection without neoadjuvant therapy, elevated Cyfra 21-1, higher T stage, and TCs and NETTs were associated with a poorer 5-year FFR in Cox regression analysis. There were significant differences in 5-year FFR between an elevated Cyfra 21-1 level and a normal Cyfra 21-1 level (42.9% vs. 92.4%, P<0.001). As for histological subtypes, TCs and NETTs were associated with a poorer 5-year FFR than thymomas (59.8% vs. 95.0%, P<0.001). CONCLUSIONS: Serum Cyfra 21-1 level could be a potential tumor marker in the diagnosis of thymic carcinomas and NETTs, and the prognosis of recurrence. AME Publishing Company 2022-12-30 /pmc/articles/PMC9792826/ http://dx.doi.org/10.21037/med-22-ab010 Text en 2022 Mediastinum. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Abstract
Hao, Xiuxiu
Zhang, Xuefei
Fang, Wentao
AB010. Clinical significance of serum Cyfra 21-1 as a marker in thymic epithelial tumors
title AB010. Clinical significance of serum Cyfra 21-1 as a marker in thymic epithelial tumors
title_full AB010. Clinical significance of serum Cyfra 21-1 as a marker in thymic epithelial tumors
title_fullStr AB010. Clinical significance of serum Cyfra 21-1 as a marker in thymic epithelial tumors
title_full_unstemmed AB010. Clinical significance of serum Cyfra 21-1 as a marker in thymic epithelial tumors
title_short AB010. Clinical significance of serum Cyfra 21-1 as a marker in thymic epithelial tumors
title_sort ab010. clinical significance of serum cyfra 21-1 as a marker in thymic epithelial tumors
topic Abstract
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792826/
http://dx.doi.org/10.21037/med-22-ab010
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