Epilepsy gene prickle ensures neuropil glial ensheathment through regulating cell adhesion molecules

Human PRICKLE1 gene has been associated with epilepsy. However, the underlying pathogenetic mechanisms remain elusive. Here we report a Drosophila prickle mutant pk(IG1-1) exhibiting strong epileptic seizures and, intriguingly, abnormal glial wrapping. We found that pk is required in both neurons an...

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Detalles Bibliográficos
Autores principales: Chen, Yanbo, Liu, Tong-Tong, Niu, Mengxia, Li, Xiaoting, Wang, Xinwei, Liu, Tong, Li, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792895/
https://www.ncbi.nlm.nih.gov/pubmed/36582832
http://dx.doi.org/10.1016/j.isci.2022.105731

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792895/
https://www.ncbi.nlm.nih.gov/pubmed/36582832
http://dx.doi.org/10.1016/j.isci.2022.105731

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