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Epilepsy gene prickle ensures neuropil glial ensheathment through regulating cell adhesion molecules
Human PRICKLE1 gene has been associated with epilepsy. However, the underlying pathogenetic mechanisms remain elusive. Here we report a Drosophila prickle mutant pk(IG1-1) exhibiting strong epileptic seizures and, intriguingly, abnormal glial wrapping. We found that pk is required in both neurons an...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792895/ https://www.ncbi.nlm.nih.gov/pubmed/36582832 http://dx.doi.org/10.1016/j.isci.2022.105731 |