ALDH2 deficiency increases susceptibility to binge alcohol-induced gut leakiness, endotoxemia, and acute liver injury in mice through the gut-liver axis

Mitochondrial aldehyde dehydrogenase 2 (ALDH2) is the major enzyme responsible for metabolizing toxic acetaldehyde to acetate and acts as a protective or defensive protein against various disease states associated with alcohol use disorder (AUD), including alcohol-related liver disease (ARLD). We hy...

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Detalles Bibliográficos
Autores principales: Rungratanawanich, Wiramon, Lin, Yuhong, Wang, Xin, Kawamoto, Toshihiro, Chidambaram, Saravana Babu, Song, Byoung-Joon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792909/
https://www.ncbi.nlm.nih.gov/pubmed/36528936
http://dx.doi.org/10.1016/j.redox.2022.102577

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