Cargando…

Statins block mammalian target of rapamycin pathway: a possible novel therapeutic strategy for inflammatory, malignant and neurodegenerative diseases

Inflammation plays a critical role in several diseases such as cancer, gastric, heart and nervous system diseases. Data suggest that the activation of mammalian target of rapamycin (mTOR) pathway in epithelial cells leads to inflammation. Statins, the inhibitors of the 3-hydroxy-3-methylglutaryl-coe...

Descripción completa

Detalles Bibliográficos
Autores principales: Lashgari, Naser-Aldin, Roudsari, Nazanin Momeni, Zadeh, Seyed Saeed Tamehri, Momtaz, Saeideh, Abbasifard, Mitra, Reiner, Željko, Abdolghaffari, Amir Hossein, Sahebkar, Amirhossein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792946/
https://www.ncbi.nlm.nih.gov/pubmed/36574095
http://dx.doi.org/10.1007/s10787-022-01077-w
_version_ 1784859745983660032
author Lashgari, Naser-Aldin
Roudsari, Nazanin Momeni
Zadeh, Seyed Saeed Tamehri
Momtaz, Saeideh
Abbasifard, Mitra
Reiner, Željko
Abdolghaffari, Amir Hossein
Sahebkar, Amirhossein
author_facet Lashgari, Naser-Aldin
Roudsari, Nazanin Momeni
Zadeh, Seyed Saeed Tamehri
Momtaz, Saeideh
Abbasifard, Mitra
Reiner, Željko
Abdolghaffari, Amir Hossein
Sahebkar, Amirhossein
author_sort Lashgari, Naser-Aldin
collection PubMed
description Inflammation plays a critical role in several diseases such as cancer, gastric, heart and nervous system diseases. Data suggest that the activation of mammalian target of rapamycin (mTOR) pathway in epithelial cells leads to inflammation. Statins, the inhibitors of the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA), seem to be able to inhibit the mTOR. Statins are considered to have favorable effects on inflammatory diseases by reducing the complications caused by inflammation and by regulating the inflammatory process and cytokines secretion. This critical review collected data on this topic from clinical, in vivo and in vitro studies published between 1998 and June 2022 in English from databases including PubMed, Google Scholar, Scopus, and Cochrane libraries.
format Online
Article
Text
id pubmed-9792946
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Springer International Publishing
record_format MEDLINE/PubMed
spelling pubmed-97929462022-12-27 Statins block mammalian target of rapamycin pathway: a possible novel therapeutic strategy for inflammatory, malignant and neurodegenerative diseases Lashgari, Naser-Aldin Roudsari, Nazanin Momeni Zadeh, Seyed Saeed Tamehri Momtaz, Saeideh Abbasifard, Mitra Reiner, Željko Abdolghaffari, Amir Hossein Sahebkar, Amirhossein Inflammopharmacology Review Inflammation plays a critical role in several diseases such as cancer, gastric, heart and nervous system diseases. Data suggest that the activation of mammalian target of rapamycin (mTOR) pathway in epithelial cells leads to inflammation. Statins, the inhibitors of the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA), seem to be able to inhibit the mTOR. Statins are considered to have favorable effects on inflammatory diseases by reducing the complications caused by inflammation and by regulating the inflammatory process and cytokines secretion. This critical review collected data on this topic from clinical, in vivo and in vitro studies published between 1998 and June 2022 in English from databases including PubMed, Google Scholar, Scopus, and Cochrane libraries. Springer International Publishing 2022-12-27 2023 /pmc/articles/PMC9792946/ /pubmed/36574095 http://dx.doi.org/10.1007/s10787-022-01077-w Text en © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review
Lashgari, Naser-Aldin
Roudsari, Nazanin Momeni
Zadeh, Seyed Saeed Tamehri
Momtaz, Saeideh
Abbasifard, Mitra
Reiner, Željko
Abdolghaffari, Amir Hossein
Sahebkar, Amirhossein
Statins block mammalian target of rapamycin pathway: a possible novel therapeutic strategy for inflammatory, malignant and neurodegenerative diseases
title Statins block mammalian target of rapamycin pathway: a possible novel therapeutic strategy for inflammatory, malignant and neurodegenerative diseases
title_full Statins block mammalian target of rapamycin pathway: a possible novel therapeutic strategy for inflammatory, malignant and neurodegenerative diseases
title_fullStr Statins block mammalian target of rapamycin pathway: a possible novel therapeutic strategy for inflammatory, malignant and neurodegenerative diseases
title_full_unstemmed Statins block mammalian target of rapamycin pathway: a possible novel therapeutic strategy for inflammatory, malignant and neurodegenerative diseases
title_short Statins block mammalian target of rapamycin pathway: a possible novel therapeutic strategy for inflammatory, malignant and neurodegenerative diseases
title_sort statins block mammalian target of rapamycin pathway: a possible novel therapeutic strategy for inflammatory, malignant and neurodegenerative diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792946/
https://www.ncbi.nlm.nih.gov/pubmed/36574095
http://dx.doi.org/10.1007/s10787-022-01077-w
work_keys_str_mv AT lashgarinaseraldin statinsblockmammaliantargetofrapamycinpathwayapossiblenoveltherapeuticstrategyforinflammatorymalignantandneurodegenerativediseases
AT roudsarinazaninmomeni statinsblockmammaliantargetofrapamycinpathwayapossiblenoveltherapeuticstrategyforinflammatorymalignantandneurodegenerativediseases
AT zadehseyedsaeedtamehri statinsblockmammaliantargetofrapamycinpathwayapossiblenoveltherapeuticstrategyforinflammatorymalignantandneurodegenerativediseases
AT momtazsaeideh statinsblockmammaliantargetofrapamycinpathwayapossiblenoveltherapeuticstrategyforinflammatorymalignantandneurodegenerativediseases
AT abbasifardmitra statinsblockmammaliantargetofrapamycinpathwayapossiblenoveltherapeuticstrategyforinflammatorymalignantandneurodegenerativediseases
AT reinerzeljko statinsblockmammaliantargetofrapamycinpathwayapossiblenoveltherapeuticstrategyforinflammatorymalignantandneurodegenerativediseases
AT abdolghaffariamirhossein statinsblockmammaliantargetofrapamycinpathwayapossiblenoveltherapeuticstrategyforinflammatorymalignantandneurodegenerativediseases
AT sahebkaramirhossein statinsblockmammaliantargetofrapamycinpathwayapossiblenoveltherapeuticstrategyforinflammatorymalignantandneurodegenerativediseases