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Statins block mammalian target of rapamycin pathway: a possible novel therapeutic strategy for inflammatory, malignant and neurodegenerative diseases
Inflammation plays a critical role in several diseases such as cancer, gastric, heart and nervous system diseases. Data suggest that the activation of mammalian target of rapamycin (mTOR) pathway in epithelial cells leads to inflammation. Statins, the inhibitors of the 3-hydroxy-3-methylglutaryl-coe...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792946/ https://www.ncbi.nlm.nih.gov/pubmed/36574095 http://dx.doi.org/10.1007/s10787-022-01077-w |
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author | Lashgari, Naser-Aldin Roudsari, Nazanin Momeni Zadeh, Seyed Saeed Tamehri Momtaz, Saeideh Abbasifard, Mitra Reiner, Željko Abdolghaffari, Amir Hossein Sahebkar, Amirhossein |
author_facet | Lashgari, Naser-Aldin Roudsari, Nazanin Momeni Zadeh, Seyed Saeed Tamehri Momtaz, Saeideh Abbasifard, Mitra Reiner, Željko Abdolghaffari, Amir Hossein Sahebkar, Amirhossein |
author_sort | Lashgari, Naser-Aldin |
collection | PubMed |
description | Inflammation plays a critical role in several diseases such as cancer, gastric, heart and nervous system diseases. Data suggest that the activation of mammalian target of rapamycin (mTOR) pathway in epithelial cells leads to inflammation. Statins, the inhibitors of the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA), seem to be able to inhibit the mTOR. Statins are considered to have favorable effects on inflammatory diseases by reducing the complications caused by inflammation and by regulating the inflammatory process and cytokines secretion. This critical review collected data on this topic from clinical, in vivo and in vitro studies published between 1998 and June 2022 in English from databases including PubMed, Google Scholar, Scopus, and Cochrane libraries. |
format | Online Article Text |
id | pubmed-9792946 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-97929462022-12-27 Statins block mammalian target of rapamycin pathway: a possible novel therapeutic strategy for inflammatory, malignant and neurodegenerative diseases Lashgari, Naser-Aldin Roudsari, Nazanin Momeni Zadeh, Seyed Saeed Tamehri Momtaz, Saeideh Abbasifard, Mitra Reiner, Željko Abdolghaffari, Amir Hossein Sahebkar, Amirhossein Inflammopharmacology Review Inflammation plays a critical role in several diseases such as cancer, gastric, heart and nervous system diseases. Data suggest that the activation of mammalian target of rapamycin (mTOR) pathway in epithelial cells leads to inflammation. Statins, the inhibitors of the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA), seem to be able to inhibit the mTOR. Statins are considered to have favorable effects on inflammatory diseases by reducing the complications caused by inflammation and by regulating the inflammatory process and cytokines secretion. This critical review collected data on this topic from clinical, in vivo and in vitro studies published between 1998 and June 2022 in English from databases including PubMed, Google Scholar, Scopus, and Cochrane libraries. Springer International Publishing 2022-12-27 2023 /pmc/articles/PMC9792946/ /pubmed/36574095 http://dx.doi.org/10.1007/s10787-022-01077-w Text en © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Review Lashgari, Naser-Aldin Roudsari, Nazanin Momeni Zadeh, Seyed Saeed Tamehri Momtaz, Saeideh Abbasifard, Mitra Reiner, Željko Abdolghaffari, Amir Hossein Sahebkar, Amirhossein Statins block mammalian target of rapamycin pathway: a possible novel therapeutic strategy for inflammatory, malignant and neurodegenerative diseases |
title | Statins block mammalian target of rapamycin pathway: a possible novel therapeutic strategy for inflammatory, malignant and neurodegenerative diseases |
title_full | Statins block mammalian target of rapamycin pathway: a possible novel therapeutic strategy for inflammatory, malignant and neurodegenerative diseases |
title_fullStr | Statins block mammalian target of rapamycin pathway: a possible novel therapeutic strategy for inflammatory, malignant and neurodegenerative diseases |
title_full_unstemmed | Statins block mammalian target of rapamycin pathway: a possible novel therapeutic strategy for inflammatory, malignant and neurodegenerative diseases |
title_short | Statins block mammalian target of rapamycin pathway: a possible novel therapeutic strategy for inflammatory, malignant and neurodegenerative diseases |
title_sort | statins block mammalian target of rapamycin pathway: a possible novel therapeutic strategy for inflammatory, malignant and neurodegenerative diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792946/ https://www.ncbi.nlm.nih.gov/pubmed/36574095 http://dx.doi.org/10.1007/s10787-022-01077-w |
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