Toxic effect and inability of L-homoserine to be a nitrogen source for growth of Escherichia coli resolved by a combination of in vivo evolution engineering and omics analyses

L-homoserine is a pivotal intermediate in the carbon and nitrogen metabolism of E. coli. However, this non-canonical amino acid cannot be used as a nitrogen source for growth. Furthermore, growth of this bacterium in a synthetic media is potently inhibited by L-homoserine. To understand this dual ef...

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Detalles Bibliográficos
Autores principales: Alkim, Ceren, Farias, Daniele, Fredonnet, Julie, Serrano-Bataille, Helene, Herviou, Pauline, Picot, Marc, Slama, Nawel, Dejean, Sebastien, Morin, Nicolas, Enjalbert, Brice, François, Jean M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792984/
https://www.ncbi.nlm.nih.gov/pubmed/36583047
http://dx.doi.org/10.3389/fmicb.2022.1051425

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