Clinical Impact of Noninvasive Plasma Microbial Cell-Free Deoxyribonucleic Acid Sequencing for the Diagnosis and Management of Pneumocystis jirovecii Pneumonia: A Single-Center Retrospective Study

We present 23 cases of Pneumocystis jirovecii pneumonia (PCP) diagnosed with commercially available noninvasive plasma microbial cell-free deoxyribonucleic acid (mcfDNA) assay. Our findings suggest that plasma mcfDNA testing resulted in positive clinical impact for the diagnosis and treatment of PCP...

Descripción completa

Detalles Bibliográficos
Autores principales: Foong, Kap Sum, Mabayoje, Mojolaoluwa, AlMajali, Abeer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9793099/
https://www.ncbi.nlm.nih.gov/pubmed/36578518
http://dx.doi.org/10.1093/ofid/ofac652
_version_ 1784859783320305664
author Foong, Kap Sum
Mabayoje, Mojolaoluwa
AlMajali, Abeer
author_facet Foong, Kap Sum
Mabayoje, Mojolaoluwa
AlMajali, Abeer
author_sort Foong, Kap Sum
collection PubMed
description We present 23 cases of Pneumocystis jirovecii pneumonia (PCP) diagnosed with commercially available noninvasive plasma microbial cell-free deoxyribonucleic acid (mcfDNA) assay. Our findings suggest that plasma mcfDNA testing resulted in positive clinical impact for the diagnosis and treatment of PCP and coinfections in 82.6% of cases.
format Online
Article
Text
id pubmed-9793099
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-97930992022-12-27 Clinical Impact of Noninvasive Plasma Microbial Cell-Free Deoxyribonucleic Acid Sequencing for the Diagnosis and Management of Pneumocystis jirovecii Pneumonia: A Single-Center Retrospective Study Foong, Kap Sum Mabayoje, Mojolaoluwa AlMajali, Abeer Open Forum Infect Dis Brief Report We present 23 cases of Pneumocystis jirovecii pneumonia (PCP) diagnosed with commercially available noninvasive plasma microbial cell-free deoxyribonucleic acid (mcfDNA) assay. Our findings suggest that plasma mcfDNA testing resulted in positive clinical impact for the diagnosis and treatment of PCP and coinfections in 82.6% of cases. Oxford University Press 2022-12-02 /pmc/articles/PMC9793099/ /pubmed/36578518 http://dx.doi.org/10.1093/ofid/ofac652 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Foong, Kap Sum
Mabayoje, Mojolaoluwa
AlMajali, Abeer
Clinical Impact of Noninvasive Plasma Microbial Cell-Free Deoxyribonucleic Acid Sequencing for the Diagnosis and Management of Pneumocystis jirovecii Pneumonia: A Single-Center Retrospective Study
title Clinical Impact of Noninvasive Plasma Microbial Cell-Free Deoxyribonucleic Acid Sequencing for the Diagnosis and Management of Pneumocystis jirovecii Pneumonia: A Single-Center Retrospective Study
title_full Clinical Impact of Noninvasive Plasma Microbial Cell-Free Deoxyribonucleic Acid Sequencing for the Diagnosis and Management of Pneumocystis jirovecii Pneumonia: A Single-Center Retrospective Study
title_fullStr Clinical Impact of Noninvasive Plasma Microbial Cell-Free Deoxyribonucleic Acid Sequencing for the Diagnosis and Management of Pneumocystis jirovecii Pneumonia: A Single-Center Retrospective Study
title_full_unstemmed Clinical Impact of Noninvasive Plasma Microbial Cell-Free Deoxyribonucleic Acid Sequencing for the Diagnosis and Management of Pneumocystis jirovecii Pneumonia: A Single-Center Retrospective Study
title_short Clinical Impact of Noninvasive Plasma Microbial Cell-Free Deoxyribonucleic Acid Sequencing for the Diagnosis and Management of Pneumocystis jirovecii Pneumonia: A Single-Center Retrospective Study
title_sort clinical impact of noninvasive plasma microbial cell-free deoxyribonucleic acid sequencing for the diagnosis and management of pneumocystis jirovecii pneumonia: a single-center retrospective study
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9793099/
https://www.ncbi.nlm.nih.gov/pubmed/36578518
http://dx.doi.org/10.1093/ofid/ofac652
work_keys_str_mv AT foongkapsum clinicalimpactofnoninvasiveplasmamicrobialcellfreedeoxyribonucleicacidsequencingforthediagnosisandmanagementofpneumocystisjiroveciipneumoniaasinglecenterretrospectivestudy
AT mabayojemojolaoluwa clinicalimpactofnoninvasiveplasmamicrobialcellfreedeoxyribonucleicacidsequencingforthediagnosisandmanagementofpneumocystisjiroveciipneumoniaasinglecenterretrospectivestudy
AT almajaliabeer clinicalimpactofnoninvasiveplasmamicrobialcellfreedeoxyribonucleicacidsequencingforthediagnosisandmanagementofpneumocystisjiroveciipneumoniaasinglecenterretrospectivestudy

Ejemplares similares