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Two-way association between alopecia areata and sleep disorders: A systematic review of observational studies
BACKGROUND: Alopecia Areata (AA) is found to be the most prevalent autoimmune disorder amongst the general population. It was observed that AA patients are at a significantly higher risk of developing obstructive sleep apnea and non-apneic insomnia than patients without AA. On the contrary, patients...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9793131/ https://www.ncbi.nlm.nih.gov/pubmed/36582873 http://dx.doi.org/10.1016/j.amsu.2022.104820 |
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author | Rehan, Syeda Tayyaba Khan, Zayeema Mansoor, Hussain Shuja, Syed Hasan Hasan, Mohammad Mehedi |
author_facet | Rehan, Syeda Tayyaba Khan, Zayeema Mansoor, Hussain Shuja, Syed Hasan Hasan, Mohammad Mehedi |
author_sort | Rehan, Syeda Tayyaba |
collection | PubMed |
description | BACKGROUND: Alopecia Areata (AA) is found to be the most prevalent autoimmune disorder amongst the general population. It was observed that AA patients are at a significantly higher risk of developing obstructive sleep apnea and non-apneic insomnia than patients without AA. On the contrary, patients with identified sleep disorders were found to be more prone to developing AA as compared to the patients without sleep disorders. This study, therefore, validated the hypothesis of a bidirectional association between AA and sleep disorders. AIMS: In this systematic review, our primary aim is to assess the prevalence of sleep disorders in Alopecia Areata patients while also assessing the inverse relationship between the two disorders. METHODS: A literature search of MEDLINE, Google Scholar and Cochrane CENTRAL was performed from their inception to April 2022. Articles were selected for inclusion if they met the following eligibility criteria: (a) Studies enrolling patients having alopecia areata to assess the sleep quality. (b) Studies assessing the risks of alopecia areata in individuals with sleep disorder (c) Studies evaluating the bidirectional association between alopecia areata and sleep quality. Case reports, commentaries, and editorials were excluded. The outcomes of recruited studies were qualitatively synthesised and study findings are summarized in the results section and tabulated in summary tables. RESULTS: Our search on electronic databases yielded 1562 articles. After abstract screening and full text review, 5 cross sectional and 3 cohort studies are included in this systematic review. Cases with PSQI scores higher than 5 and 6 were found to be in greater numbers amongst the AA patient population when compared to the control population (p < 0.001). Moreover, studies showed that patients with sleep disorders were greatly predisposed to develop subsequent AA as compared to patients without sleep disorders (aHR 4.70; 95% CI 3.99–5.54) (P < 0.0001). CONCLUSION: The findings from our results display a significant bi-directional cause-effect relation between AA and sleep disorders. However, more large-scale observational studies on this subject are required to further validate our findings. |
format | Online Article Text |
id | pubmed-9793131 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-97931312022-12-28 Two-way association between alopecia areata and sleep disorders: A systematic review of observational studies Rehan, Syeda Tayyaba Khan, Zayeema Mansoor, Hussain Shuja, Syed Hasan Hasan, Mohammad Mehedi Ann Med Surg (Lond) Systematic Review / Meta-analysis BACKGROUND: Alopecia Areata (AA) is found to be the most prevalent autoimmune disorder amongst the general population. It was observed that AA patients are at a significantly higher risk of developing obstructive sleep apnea and non-apneic insomnia than patients without AA. On the contrary, patients with identified sleep disorders were found to be more prone to developing AA as compared to the patients without sleep disorders. This study, therefore, validated the hypothesis of a bidirectional association between AA and sleep disorders. AIMS: In this systematic review, our primary aim is to assess the prevalence of sleep disorders in Alopecia Areata patients while also assessing the inverse relationship between the two disorders. METHODS: A literature search of MEDLINE, Google Scholar and Cochrane CENTRAL was performed from their inception to April 2022. Articles were selected for inclusion if they met the following eligibility criteria: (a) Studies enrolling patients having alopecia areata to assess the sleep quality. (b) Studies assessing the risks of alopecia areata in individuals with sleep disorder (c) Studies evaluating the bidirectional association between alopecia areata and sleep quality. Case reports, commentaries, and editorials were excluded. The outcomes of recruited studies were qualitatively synthesised and study findings are summarized in the results section and tabulated in summary tables. RESULTS: Our search on electronic databases yielded 1562 articles. After abstract screening and full text review, 5 cross sectional and 3 cohort studies are included in this systematic review. Cases with PSQI scores higher than 5 and 6 were found to be in greater numbers amongst the AA patient population when compared to the control population (p < 0.001). Moreover, studies showed that patients with sleep disorders were greatly predisposed to develop subsequent AA as compared to patients without sleep disorders (aHR 4.70; 95% CI 3.99–5.54) (P < 0.0001). CONCLUSION: The findings from our results display a significant bi-directional cause-effect relation between AA and sleep disorders. However, more large-scale observational studies on this subject are required to further validate our findings. Elsevier 2022-11-05 /pmc/articles/PMC9793131/ /pubmed/36582873 http://dx.doi.org/10.1016/j.amsu.2022.104820 Text en © 2022 Published by Elsevier Ltd on behalf of IJS Publishing Group Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Systematic Review / Meta-analysis Rehan, Syeda Tayyaba Khan, Zayeema Mansoor, Hussain Shuja, Syed Hasan Hasan, Mohammad Mehedi Two-way association between alopecia areata and sleep disorders: A systematic review of observational studies |
title | Two-way association between alopecia areata and sleep disorders: A systematic review of observational studies |
title_full | Two-way association between alopecia areata and sleep disorders: A systematic review of observational studies |
title_fullStr | Two-way association between alopecia areata and sleep disorders: A systematic review of observational studies |
title_full_unstemmed | Two-way association between alopecia areata and sleep disorders: A systematic review of observational studies |
title_short | Two-way association between alopecia areata and sleep disorders: A systematic review of observational studies |
title_sort | two-way association between alopecia areata and sleep disorders: a systematic review of observational studies |
topic | Systematic Review / Meta-analysis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9793131/ https://www.ncbi.nlm.nih.gov/pubmed/36582873 http://dx.doi.org/10.1016/j.amsu.2022.104820 |
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