Cargando…

Bulbar onset amyotrophic lateral sclerosis: A case report

INTRODUCTION: Amyotrophic lateral sclerosis is a rare progressive neurodegenerative disease that affects the brain and spinal cord nerve cells. The study highlights the role of early diagnosis and prognosis of bulbar onset ALS. CASE PRESENTATION: We present a case of 60 years old female who presente...

Descripción completa

Detalles Bibliográficos
Autores principales: Pudasaini, Prasamsa, Neupane, Shashank, Dhakal, Bishal, Rana, Abilasha, Pathak, Bishnu Deep, Dawadi, Sagun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9793157/
https://www.ncbi.nlm.nih.gov/pubmed/36582871
http://dx.doi.org/10.1016/j.amsu.2022.104889
_version_ 1784859796729495552
author Pudasaini, Prasamsa
Neupane, Shashank
Dhakal, Bishal
Rana, Abilasha
Pathak, Bishnu Deep
Dawadi, Sagun
author_facet Pudasaini, Prasamsa
Neupane, Shashank
Dhakal, Bishal
Rana, Abilasha
Pathak, Bishnu Deep
Dawadi, Sagun
author_sort Pudasaini, Prasamsa
collection PubMed
description INTRODUCTION: Amyotrophic lateral sclerosis is a rare progressive neurodegenerative disease that affects the brain and spinal cord nerve cells. The study highlights the role of early diagnosis and prognosis of bulbar onset ALS. CASE PRESENTATION: We present a case of 60 years old female who presented with slurring of speech with a deviation of tongue and progressive dysphagia. With the role of Magnetic Resonance Imaging (MRI), Electromyography (EMG) and Nerve Conduction Study (NCS), a diagnosis of ALS was made. CLINICAL DISCUSSION: ALS is a progressive neurodegenerative disorder, and the presence of genioglossus muscle involvement at diagnosis implies a shorter survival. It mandates multidisciplinary aspects requiring a professional opinion from neurologists, speech therapists, otolaryngologists, and electrophysiologists for effective treatment. Edaravone has antioxidant properties which counteract oxidative stress leading to neuronal injury in patients with ALS. CONCLUSION: ALS with bulbar onset can have a grave prognosis and hence requires a multidisciplinary approach toward effective treatment.
format Online
Article
Text
id pubmed-9793157
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-97931572022-12-28 Bulbar onset amyotrophic lateral sclerosis: A case report Pudasaini, Prasamsa Neupane, Shashank Dhakal, Bishal Rana, Abilasha Pathak, Bishnu Deep Dawadi, Sagun Ann Med Surg (Lond) Case Report INTRODUCTION: Amyotrophic lateral sclerosis is a rare progressive neurodegenerative disease that affects the brain and spinal cord nerve cells. The study highlights the role of early diagnosis and prognosis of bulbar onset ALS. CASE PRESENTATION: We present a case of 60 years old female who presented with slurring of speech with a deviation of tongue and progressive dysphagia. With the role of Magnetic Resonance Imaging (MRI), Electromyography (EMG) and Nerve Conduction Study (NCS), a diagnosis of ALS was made. CLINICAL DISCUSSION: ALS is a progressive neurodegenerative disorder, and the presence of genioglossus muscle involvement at diagnosis implies a shorter survival. It mandates multidisciplinary aspects requiring a professional opinion from neurologists, speech therapists, otolaryngologists, and electrophysiologists for effective treatment. Edaravone has antioxidant properties which counteract oxidative stress leading to neuronal injury in patients with ALS. CONCLUSION: ALS with bulbar onset can have a grave prognosis and hence requires a multidisciplinary approach toward effective treatment. Elsevier 2022-11-13 /pmc/articles/PMC9793157/ /pubmed/36582871 http://dx.doi.org/10.1016/j.amsu.2022.104889 Text en © 2022 Published by Elsevier Ltd on behalf of IJS Publishing Group Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Pudasaini, Prasamsa
Neupane, Shashank
Dhakal, Bishal
Rana, Abilasha
Pathak, Bishnu Deep
Dawadi, Sagun
Bulbar onset amyotrophic lateral sclerosis: A case report
title Bulbar onset amyotrophic lateral sclerosis: A case report
title_full Bulbar onset amyotrophic lateral sclerosis: A case report
title_fullStr Bulbar onset amyotrophic lateral sclerosis: A case report
title_full_unstemmed Bulbar onset amyotrophic lateral sclerosis: A case report
title_short Bulbar onset amyotrophic lateral sclerosis: A case report
title_sort bulbar onset amyotrophic lateral sclerosis: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9793157/
https://www.ncbi.nlm.nih.gov/pubmed/36582871
http://dx.doi.org/10.1016/j.amsu.2022.104889
work_keys_str_mv AT pudasainiprasamsa bulbaronsetamyotrophiclateralsclerosisacasereport
AT neupaneshashank bulbaronsetamyotrophiclateralsclerosisacasereport
AT dhakalbishal bulbaronsetamyotrophiclateralsclerosisacasereport
AT ranaabilasha bulbaronsetamyotrophiclateralsclerosisacasereport
AT pathakbishnudeep bulbaronsetamyotrophiclateralsclerosisacasereport
AT dawadisagun bulbaronsetamyotrophiclateralsclerosisacasereport