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Ribosomal protein RPL11 haploinsufficiency causes anemia in mice via activation of the RP-MDM2-p53 pathway

Recent discovery of the ribosomal protein (RP) RPL11 interacting with and inhibiting the E3 ubiquitin ligase function of MDM2 established the RP-MDM2-p53 signaling pathway, which is linked to biological events, including ribosomal biogenesis, nutrient availability, and metabolic homeostasis. Mutatio...

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Detalles Bibliográficos
Autores principales:	Franklin, Derek A., Liu, Shijie, Jin, Aiwen, Cui, Pengfei, Guo, Zengli, Arend, Kyle C., Moorman, Nathaniel J., He, Shenghui, Wang, Gang Greg, Wan, Yisong Y., Zhang, Yanping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9793318/ https://www.ncbi.nlm.nih.gov/pubmed/36435197 http://dx.doi.org/10.1016/j.jbc.2022.102739

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