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Genome-wide data from medieval German Jews show that the Ashkenazi founder event pre-dated the 14(th) century
We report genome-wide data from 33 Ashkenazi Jews (AJ), dated to the 14(th) century, obtained following a salvage excavation at the medieval Jewish cemetery of Erfurt, Germany. The Erfurt individuals are genetically similar to modern AJ, but they show more variability in Eastern European-related anc...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9793425/ https://www.ncbi.nlm.nih.gov/pubmed/36455558 http://dx.doi.org/10.1016/j.cell.2022.11.002 |
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author | Waldman, Shamam Backenroth, Daniel Harney, Éadaoin Flohr, Stefan Neff, Nadia C. Buckley, Gina M. Fridman, Hila Akbari, Ali Rohland, Nadin Mallick, Swapan Olalde, Iñigo Cooper, Leo Lomes, Ariel Lipson, Joshua Cano Nistal, Jorge Yu, Jin Barzilai, Nir Peter, Inga Atzmon, Gil Ostrer, Harry Lencz, Todd Maruvka, Yosef E. Lämmerhirt, Maike Beider, Alexander Rutgers, Leonard V. Renson, Virginie Prufer, Keith M. Schiffels, Stephan Ringbauer, Harald Sczech, Karin Carmi, Shai Reich, David |
author_facet | Waldman, Shamam Backenroth, Daniel Harney, Éadaoin Flohr, Stefan Neff, Nadia C. Buckley, Gina M. Fridman, Hila Akbari, Ali Rohland, Nadin Mallick, Swapan Olalde, Iñigo Cooper, Leo Lomes, Ariel Lipson, Joshua Cano Nistal, Jorge Yu, Jin Barzilai, Nir Peter, Inga Atzmon, Gil Ostrer, Harry Lencz, Todd Maruvka, Yosef E. Lämmerhirt, Maike Beider, Alexander Rutgers, Leonard V. Renson, Virginie Prufer, Keith M. Schiffels, Stephan Ringbauer, Harald Sczech, Karin Carmi, Shai Reich, David |
author_sort | Waldman, Shamam |
collection | PubMed |
description | We report genome-wide data from 33 Ashkenazi Jews (AJ), dated to the 14(th) century, obtained following a salvage excavation at the medieval Jewish cemetery of Erfurt, Germany. The Erfurt individuals are genetically similar to modern AJ, but they show more variability in Eastern European-related ancestry than modern AJ. A third of the Erfurt individuals carried a mitochondrial lineage common in modern AJ and eight carried pathogenic variants known to affect AJ today. These observations, together with high levels of runs of homozygosity, suggest that the Erfurt community had already experienced the major reduction in size that affected modern AJ. The Erfurt bottleneck was more severe, implying substructure in medieval AJ. Overall, our results suggest that the AJ founder event and the acquisition of the main sources of ancestry pre-dated the 14(th) century and highlight late medieval genetic heterogeneity no longer present in modern AJ. |
format | Online Article Text |
id | pubmed-9793425 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
record_format | MEDLINE/PubMed |
spelling | pubmed-97934252022-12-27 Genome-wide data from medieval German Jews show that the Ashkenazi founder event pre-dated the 14(th) century Waldman, Shamam Backenroth, Daniel Harney, Éadaoin Flohr, Stefan Neff, Nadia C. Buckley, Gina M. Fridman, Hila Akbari, Ali Rohland, Nadin Mallick, Swapan Olalde, Iñigo Cooper, Leo Lomes, Ariel Lipson, Joshua Cano Nistal, Jorge Yu, Jin Barzilai, Nir Peter, Inga Atzmon, Gil Ostrer, Harry Lencz, Todd Maruvka, Yosef E. Lämmerhirt, Maike Beider, Alexander Rutgers, Leonard V. Renson, Virginie Prufer, Keith M. Schiffels, Stephan Ringbauer, Harald Sczech, Karin Carmi, Shai Reich, David Cell Article We report genome-wide data from 33 Ashkenazi Jews (AJ), dated to the 14(th) century, obtained following a salvage excavation at the medieval Jewish cemetery of Erfurt, Germany. The Erfurt individuals are genetically similar to modern AJ, but they show more variability in Eastern European-related ancestry than modern AJ. A third of the Erfurt individuals carried a mitochondrial lineage common in modern AJ and eight carried pathogenic variants known to affect AJ today. These observations, together with high levels of runs of homozygosity, suggest that the Erfurt community had already experienced the major reduction in size that affected modern AJ. The Erfurt bottleneck was more severe, implying substructure in medieval AJ. Overall, our results suggest that the AJ founder event and the acquisition of the main sources of ancestry pre-dated the 14(th) century and highlight late medieval genetic heterogeneity no longer present in modern AJ. 2022-12-08 2022-11-30 /pmc/articles/PMC9793425/ /pubmed/36455558 http://dx.doi.org/10.1016/j.cell.2022.11.002 Text en https://creativecommons.org/licenses/by/4.0/This article is subject to HHMI’s Open Access to Publications policy. HHMI lab heads have previously granted a nonexclusive CC BY 4.0 license to the public and a sublicensable license to HHMI in their research articles. Pursuant to those licenses, the author-accepted manuscript of this article can be made freely available under a CC BY 4.0 license immediately upon publication. |
spellingShingle | Article Waldman, Shamam Backenroth, Daniel Harney, Éadaoin Flohr, Stefan Neff, Nadia C. Buckley, Gina M. Fridman, Hila Akbari, Ali Rohland, Nadin Mallick, Swapan Olalde, Iñigo Cooper, Leo Lomes, Ariel Lipson, Joshua Cano Nistal, Jorge Yu, Jin Barzilai, Nir Peter, Inga Atzmon, Gil Ostrer, Harry Lencz, Todd Maruvka, Yosef E. Lämmerhirt, Maike Beider, Alexander Rutgers, Leonard V. Renson, Virginie Prufer, Keith M. Schiffels, Stephan Ringbauer, Harald Sczech, Karin Carmi, Shai Reich, David Genome-wide data from medieval German Jews show that the Ashkenazi founder event pre-dated the 14(th) century |
title | Genome-wide data from medieval German Jews show that the Ashkenazi founder event pre-dated the 14(th) century |
title_full | Genome-wide data from medieval German Jews show that the Ashkenazi founder event pre-dated the 14(th) century |
title_fullStr | Genome-wide data from medieval German Jews show that the Ashkenazi founder event pre-dated the 14(th) century |
title_full_unstemmed | Genome-wide data from medieval German Jews show that the Ashkenazi founder event pre-dated the 14(th) century |
title_short | Genome-wide data from medieval German Jews show that the Ashkenazi founder event pre-dated the 14(th) century |
title_sort | genome-wide data from medieval german jews show that the ashkenazi founder event pre-dated the 14(th) century |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9793425/ https://www.ncbi.nlm.nih.gov/pubmed/36455558 http://dx.doi.org/10.1016/j.cell.2022.11.002 |
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