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Dicoumarol: from chemistry to antitumor benefits
Dicoumarol, a coumarin-like compound, is known for its anticoagulant properties associated with the ability to inhibit vitamin K, being prescribed as a drug for several decades. The pharmaceutical value of dicoumarol turned it into a focus of chemists’ attention, aiming its synthesis and of dicoumar...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9793554/ https://www.ncbi.nlm.nih.gov/pubmed/36575479 http://dx.doi.org/10.1186/s13020-022-00699-0 |
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author | Silva, Vera L. M. Silva-Reis, Rita Moreira-Pais, Alexandra Ferreira, Tiago Oliveira, Paula A. Ferreira, Rita Cardoso, Susana M. Sharifi-Rad, Javad Butnariu, Monica Costea, Maria Alina Grozea, Ioana |
author_facet | Silva, Vera L. M. Silva-Reis, Rita Moreira-Pais, Alexandra Ferreira, Tiago Oliveira, Paula A. Ferreira, Rita Cardoso, Susana M. Sharifi-Rad, Javad Butnariu, Monica Costea, Maria Alina Grozea, Ioana |
author_sort | Silva, Vera L. M. |
collection | PubMed |
description | Dicoumarol, a coumarin-like compound, is known for its anticoagulant properties associated with the ability to inhibit vitamin K, being prescribed as a drug for several decades. The pharmaceutical value of dicoumarol turned it into a focus of chemists’ attention, aiming its synthesis and of dicoumarol derivatives, bringing to light new methodologies. In recent years, several other bioactive effects have been claimed for dicoumarol and its derivatives, including anti-inflammatory, antimicrobial, antifungal, and anticancer, although the mechanisms of action underlying them are mostly not disclosed and additional research is needed to unravel them. This review presents a state of the art on the chemistry of dicoumarols, and their potential anticancer characteristics, highlighting the mechanisms of action elucidated so far. In parallel, we draw attention to the lack of in vivo studies and clinical trials to assess the safety and efficacy as drugs for later application. |
format | Online Article Text |
id | pubmed-9793554 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-97935542022-12-28 Dicoumarol: from chemistry to antitumor benefits Silva, Vera L. M. Silva-Reis, Rita Moreira-Pais, Alexandra Ferreira, Tiago Oliveira, Paula A. Ferreira, Rita Cardoso, Susana M. Sharifi-Rad, Javad Butnariu, Monica Costea, Maria Alina Grozea, Ioana Chin Med Review Dicoumarol, a coumarin-like compound, is known for its anticoagulant properties associated with the ability to inhibit vitamin K, being prescribed as a drug for several decades. The pharmaceutical value of dicoumarol turned it into a focus of chemists’ attention, aiming its synthesis and of dicoumarol derivatives, bringing to light new methodologies. In recent years, several other bioactive effects have been claimed for dicoumarol and its derivatives, including anti-inflammatory, antimicrobial, antifungal, and anticancer, although the mechanisms of action underlying them are mostly not disclosed and additional research is needed to unravel them. This review presents a state of the art on the chemistry of dicoumarols, and their potential anticancer characteristics, highlighting the mechanisms of action elucidated so far. In parallel, we draw attention to the lack of in vivo studies and clinical trials to assess the safety and efficacy as drugs for later application. BioMed Central 2022-12-27 /pmc/articles/PMC9793554/ /pubmed/36575479 http://dx.doi.org/10.1186/s13020-022-00699-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Silva, Vera L. M. Silva-Reis, Rita Moreira-Pais, Alexandra Ferreira, Tiago Oliveira, Paula A. Ferreira, Rita Cardoso, Susana M. Sharifi-Rad, Javad Butnariu, Monica Costea, Maria Alina Grozea, Ioana Dicoumarol: from chemistry to antitumor benefits |
title | Dicoumarol: from chemistry to antitumor benefits |
title_full | Dicoumarol: from chemistry to antitumor benefits |
title_fullStr | Dicoumarol: from chemistry to antitumor benefits |
title_full_unstemmed | Dicoumarol: from chemistry to antitumor benefits |
title_short | Dicoumarol: from chemistry to antitumor benefits |
title_sort | dicoumarol: from chemistry to antitumor benefits |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9793554/ https://www.ncbi.nlm.nih.gov/pubmed/36575479 http://dx.doi.org/10.1186/s13020-022-00699-0 |
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