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Improved joint and patient-reported health assessments with pegloticase plus methotrexate co-therapy in patients with uncontrolled gout: 12-month exploratory outcomes of the MIRROR open-label trial

BACKGROUND: Uncontrolled/refractory gout patients are recalcitrant/intolerant to oral urate-lowering therapies (ULTs), experiencing frequent gout flares, functionally limiting tophi, and low quality of life. Pegloticase lowers urate, but anti-pegloticase antibodies limit urate-lowering efficacy and...

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Detalles Bibliográficos
Autores principales:	Botson, John K., Obermeyer, Katie, LaMoreaux, Brian, Zhao, Lin, Weinblatt, Michael E., Peterson, Jeff
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9793599/ https://www.ncbi.nlm.nih.gov/pubmed/36575505 http://dx.doi.org/10.1186/s13075-022-02979-4

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