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A comparison of marker-based estimators of inbreeding and inbreeding depression
BACKGROUND: The availability of genome-wide marker data allows estimation of inbreeding coefficients (F, the probability of identity-by-descent, IBD) and, in turn, estimation of the rate of inbreeding depression (ΔID). We investigated, by computer simulations, the accuracy of the most popular estima...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9793638/ https://www.ncbi.nlm.nih.gov/pubmed/36575379 http://dx.doi.org/10.1186/s12711-022-00772-0 |
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author | Caballero, Armando Fernández, Almudena Villanueva, Beatriz Toro, Miguel A. |
author_facet | Caballero, Armando Fernández, Almudena Villanueva, Beatriz Toro, Miguel A. |
author_sort | Caballero, Armando |
collection | PubMed |
description | BACKGROUND: The availability of genome-wide marker data allows estimation of inbreeding coefficients (F, the probability of identity-by-descent, IBD) and, in turn, estimation of the rate of inbreeding depression (ΔID). We investigated, by computer simulations, the accuracy of the most popular estimators of inbreeding based on molecular markers when computing F and ΔID in populations under random mating, equalization of parental contributions, and artificially selected populations. We assessed estimators described by Li and Horvitz (F(LH1) and F(LH2)), VanRaden (F(VR1) and F(VR2)), Yang and colleagues (F(YA1) and F(YA2)), marker homozygosity (F(HOM)), runs of homozygosity (F(ROH)) and estimates based on pedigree (F(PED)) in comparison with estimates obtained from IBD measures (F(IBD)). RESULTS: If the allele frequencies of a base population taken as a reference for the computation of inbreeding are known, all estimators based on marker allele frequencies are highly correlated with F(IBD) and provide accurate estimates of the mean ΔID. If base population allele frequencies are unknown and current frequencies are used in the estimations, the largest correlation with F(IBD) is generally obtained by F(LH1) and the best estimator of ΔID is F(YA2). The estimators F(VR2) and F(LH2) have the poorest performance in most scenarios. The assumption that base population allele frequencies are equal to 0.5 results in very biased estimates of the average inbreeding coefficient but they are highly correlated with F(IBD) and give relatively good estimates of ΔID. Estimates obtained directly from marker homozygosity (F(HOM)) substantially overestimated ΔID. Estimates based on runs of homozygosity (F(ROH)) provide accurate estimates of inbreeding and ΔID. Finally, estimates based on pedigree (F(PED)) show a lower correlation with F(IBD) than molecular estimators but provide rather accurate estimates of ΔID. An analysis of data from a pig population supports the main findings of the simulations. CONCLUSIONS: When base population allele frequencies are known, all marker-allele frequency-based estimators of inbreeding coefficients generally show a high correlation with F(IBD) and provide good estimates of ΔID. When base population allele frequencies are unknown, F(LH1) is the marker frequency-based estimator that is most correlated with F(IBD), and F(YA2) provides the most accurate estimates of ΔID. Estimates from F(ROH) are also very precise in most scenarios. The estimators F(VR2) and F(LH2) have the poorest performances. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12711-022-00772-0. |
format | Online Article Text |
id | pubmed-9793638 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-97936382022-12-28 A comparison of marker-based estimators of inbreeding and inbreeding depression Caballero, Armando Fernández, Almudena Villanueva, Beatriz Toro, Miguel A. Genet Sel Evol Research Article BACKGROUND: The availability of genome-wide marker data allows estimation of inbreeding coefficients (F, the probability of identity-by-descent, IBD) and, in turn, estimation of the rate of inbreeding depression (ΔID). We investigated, by computer simulations, the accuracy of the most popular estimators of inbreeding based on molecular markers when computing F and ΔID in populations under random mating, equalization of parental contributions, and artificially selected populations. We assessed estimators described by Li and Horvitz (F(LH1) and F(LH2)), VanRaden (F(VR1) and F(VR2)), Yang and colleagues (F(YA1) and F(YA2)), marker homozygosity (F(HOM)), runs of homozygosity (F(ROH)) and estimates based on pedigree (F(PED)) in comparison with estimates obtained from IBD measures (F(IBD)). RESULTS: If the allele frequencies of a base population taken as a reference for the computation of inbreeding are known, all estimators based on marker allele frequencies are highly correlated with F(IBD) and provide accurate estimates of the mean ΔID. If base population allele frequencies are unknown and current frequencies are used in the estimations, the largest correlation with F(IBD) is generally obtained by F(LH1) and the best estimator of ΔID is F(YA2). The estimators F(VR2) and F(LH2) have the poorest performance in most scenarios. The assumption that base population allele frequencies are equal to 0.5 results in very biased estimates of the average inbreeding coefficient but they are highly correlated with F(IBD) and give relatively good estimates of ΔID. Estimates obtained directly from marker homozygosity (F(HOM)) substantially overestimated ΔID. Estimates based on runs of homozygosity (F(ROH)) provide accurate estimates of inbreeding and ΔID. Finally, estimates based on pedigree (F(PED)) show a lower correlation with F(IBD) than molecular estimators but provide rather accurate estimates of ΔID. An analysis of data from a pig population supports the main findings of the simulations. CONCLUSIONS: When base population allele frequencies are known, all marker-allele frequency-based estimators of inbreeding coefficients generally show a high correlation with F(IBD) and provide good estimates of ΔID. When base population allele frequencies are unknown, F(LH1) is the marker frequency-based estimator that is most correlated with F(IBD), and F(YA2) provides the most accurate estimates of ΔID. Estimates from F(ROH) are also very precise in most scenarios. The estimators F(VR2) and F(LH2) have the poorest performances. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12711-022-00772-0. BioMed Central 2022-12-27 /pmc/articles/PMC9793638/ /pubmed/36575379 http://dx.doi.org/10.1186/s12711-022-00772-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Caballero, Armando Fernández, Almudena Villanueva, Beatriz Toro, Miguel A. A comparison of marker-based estimators of inbreeding and inbreeding depression |
title | A comparison of marker-based estimators of inbreeding and inbreeding depression |
title_full | A comparison of marker-based estimators of inbreeding and inbreeding depression |
title_fullStr | A comparison of marker-based estimators of inbreeding and inbreeding depression |
title_full_unstemmed | A comparison of marker-based estimators of inbreeding and inbreeding depression |
title_short | A comparison of marker-based estimators of inbreeding and inbreeding depression |
title_sort | comparison of marker-based estimators of inbreeding and inbreeding depression |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9793638/ https://www.ncbi.nlm.nih.gov/pubmed/36575379 http://dx.doi.org/10.1186/s12711-022-00772-0 |
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