Cargando…

Effect of a diet based on the dietary guidelines for americans on inflammation markers in women at risk for cardiometabolic disease: results of a randomized, controlled trial

OBJECTIVE: To evaluate the effect of a diet pattern based on Dietary Guidelines for Americans (DGA), in a controlled feeding setting, on plasma markers of inflammation and on cytokine production by peripheral blood mononuclear cells (PBMC). DESIGN: Women (n = 44) with one or more risk factors of met...

Descripción completa

Detalles Bibliográficos
Autores principales: Krishnan, Sridevi, Freytag, Tammy, Jiang, Xiaowen, Schuster, Gertrud U., Woodhouse, Leslie R., Keim, Nancy L., Stephensen, Charles B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9793666/
https://www.ncbi.nlm.nih.gov/pubmed/36575541
http://dx.doi.org/10.1186/s40795-022-00647-z
_version_ 1784859885508231168
author Krishnan, Sridevi
Freytag, Tammy
Jiang, Xiaowen
Schuster, Gertrud U.
Woodhouse, Leslie R.
Keim, Nancy L.
Stephensen, Charles B.
author_facet Krishnan, Sridevi
Freytag, Tammy
Jiang, Xiaowen
Schuster, Gertrud U.
Woodhouse, Leslie R.
Keim, Nancy L.
Stephensen, Charles B.
author_sort Krishnan, Sridevi
collection PubMed
description OBJECTIVE: To evaluate the effect of a diet pattern based on Dietary Guidelines for Americans (DGA), in a controlled feeding setting, on plasma markers of inflammation and on cytokine production by peripheral blood mononuclear cells (PBMC). DESIGN: Women (n = 44) with one or more risk factors of metabolic syndrome (and BMI: 25.2-39.8 kg/m(2)) completed an 8-wk controlled feeding study. They were randomized to either a group following a diet based on DGA 2010 (DGA), or a group given a ‘typical American diet’ (TAD), based largely on a Western diet pattern. By design, women maintained their body weight. Fasting plasma and PBMC were collected at wk. 0 (baseline) and at wk. 8 (post-intervention). Sixteen plasma markers of inflammation and eight PBMC cytokines were measured at both time points, to evaluate if the diet had a significant effect on concentrations of these inflammatory markers. Data were analyzed using ANCOVA, followed by multiple-comparison adjustment using Benjamini-Hochberg method. RESULTS: Significant changes observed in Serum Amyloid A (SAA) and Matrix Metalloproteinase 3 (MMP3) in plasma did not retain significance upon multiple comparison adjustment. SAA: p = 0.044, adj p = 0.450; DGA mean change [95% CI] = − 12.6[− 32.3 to 7.04]; TAD mean change [95% CI] = − 2.24 [− 9.99 to 5.51]. MMP3: p = 0.014, adj p = 0.35; DGA mean change [95% CI] = 2.72[− 4.16 to 9.59]; TAD mean change [95% CI] = − 0.98[− 16.7 to 14.7]). Other inflammation markers were not differently altered by DGA relative to TAD. Effect size of change (Cohens d) indicated a large/medium-large effect of intervention on MMP3 and CRP, and medium effect on IL-6. CONCLUSIONS: No statistically significant changes were observed in the immune markers examined in this study. The biological roles and magnitude of the non-significant differences seen with two variables, CRP and MMP3, suggest that they be examined in future studies. TRIAL REGISTRATION: Clinicaltrials.gov identifier NCT02298725. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40795-022-00647-z.
format Online
Article
Text
id pubmed-9793666
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-97936662022-12-28 Effect of a diet based on the dietary guidelines for americans on inflammation markers in women at risk for cardiometabolic disease: results of a randomized, controlled trial Krishnan, Sridevi Freytag, Tammy Jiang, Xiaowen Schuster, Gertrud U. Woodhouse, Leslie R. Keim, Nancy L. Stephensen, Charles B. BMC Nutr Research OBJECTIVE: To evaluate the effect of a diet pattern based on Dietary Guidelines for Americans (DGA), in a controlled feeding setting, on plasma markers of inflammation and on cytokine production by peripheral blood mononuclear cells (PBMC). DESIGN: Women (n = 44) with one or more risk factors of metabolic syndrome (and BMI: 25.2-39.8 kg/m(2)) completed an 8-wk controlled feeding study. They were randomized to either a group following a diet based on DGA 2010 (DGA), or a group given a ‘typical American diet’ (TAD), based largely on a Western diet pattern. By design, women maintained their body weight. Fasting plasma and PBMC were collected at wk. 0 (baseline) and at wk. 8 (post-intervention). Sixteen plasma markers of inflammation and eight PBMC cytokines were measured at both time points, to evaluate if the diet had a significant effect on concentrations of these inflammatory markers. Data were analyzed using ANCOVA, followed by multiple-comparison adjustment using Benjamini-Hochberg method. RESULTS: Significant changes observed in Serum Amyloid A (SAA) and Matrix Metalloproteinase 3 (MMP3) in plasma did not retain significance upon multiple comparison adjustment. SAA: p = 0.044, adj p = 0.450; DGA mean change [95% CI] = − 12.6[− 32.3 to 7.04]; TAD mean change [95% CI] = − 2.24 [− 9.99 to 5.51]. MMP3: p = 0.014, adj p = 0.35; DGA mean change [95% CI] = 2.72[− 4.16 to 9.59]; TAD mean change [95% CI] = − 0.98[− 16.7 to 14.7]). Other inflammation markers were not differently altered by DGA relative to TAD. Effect size of change (Cohens d) indicated a large/medium-large effect of intervention on MMP3 and CRP, and medium effect on IL-6. CONCLUSIONS: No statistically significant changes were observed in the immune markers examined in this study. The biological roles and magnitude of the non-significant differences seen with two variables, CRP and MMP3, suggest that they be examined in future studies. TRIAL REGISTRATION: Clinicaltrials.gov identifier NCT02298725. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40795-022-00647-z. BioMed Central 2022-12-27 /pmc/articles/PMC9793666/ /pubmed/36575541 http://dx.doi.org/10.1186/s40795-022-00647-z Text en © This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Krishnan, Sridevi
Freytag, Tammy
Jiang, Xiaowen
Schuster, Gertrud U.
Woodhouse, Leslie R.
Keim, Nancy L.
Stephensen, Charles B.
Effect of a diet based on the dietary guidelines for americans on inflammation markers in women at risk for cardiometabolic disease: results of a randomized, controlled trial
title Effect of a diet based on the dietary guidelines for americans on inflammation markers in women at risk for cardiometabolic disease: results of a randomized, controlled trial
title_full Effect of a diet based on the dietary guidelines for americans on inflammation markers in women at risk for cardiometabolic disease: results of a randomized, controlled trial
title_fullStr Effect of a diet based on the dietary guidelines for americans on inflammation markers in women at risk for cardiometabolic disease: results of a randomized, controlled trial
title_full_unstemmed Effect of a diet based on the dietary guidelines for americans on inflammation markers in women at risk for cardiometabolic disease: results of a randomized, controlled trial
title_short Effect of a diet based on the dietary guidelines for americans on inflammation markers in women at risk for cardiometabolic disease: results of a randomized, controlled trial
title_sort effect of a diet based on the dietary guidelines for americans on inflammation markers in women at risk for cardiometabolic disease: results of a randomized, controlled trial
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9793666/
https://www.ncbi.nlm.nih.gov/pubmed/36575541
http://dx.doi.org/10.1186/s40795-022-00647-z
work_keys_str_mv AT krishnansridevi effectofadietbasedonthedietaryguidelinesforamericansoninflammationmarkersinwomenatriskforcardiometabolicdiseaseresultsofarandomizedcontrolledtrial
AT freytagtammy effectofadietbasedonthedietaryguidelinesforamericansoninflammationmarkersinwomenatriskforcardiometabolicdiseaseresultsofarandomizedcontrolledtrial
AT jiangxiaowen effectofadietbasedonthedietaryguidelinesforamericansoninflammationmarkersinwomenatriskforcardiometabolicdiseaseresultsofarandomizedcontrolledtrial
AT schustergertrudu effectofadietbasedonthedietaryguidelinesforamericansoninflammationmarkersinwomenatriskforcardiometabolicdiseaseresultsofarandomizedcontrolledtrial
AT woodhouseleslier effectofadietbasedonthedietaryguidelinesforamericansoninflammationmarkersinwomenatriskforcardiometabolicdiseaseresultsofarandomizedcontrolledtrial
AT keimnancyl effectofadietbasedonthedietaryguidelinesforamericansoninflammationmarkersinwomenatriskforcardiometabolicdiseaseresultsofarandomizedcontrolledtrial
AT stephensencharlesb effectofadietbasedonthedietaryguidelinesforamericansoninflammationmarkersinwomenatriskforcardiometabolicdiseaseresultsofarandomizedcontrolledtrial