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Wee1 promotes cell proliferation and imatinib resistance in chronic myeloid leukemia via regulating DNA damage repair dependent on ATM-γH2AX-MDC1

BACKGROUND: The treatment of chronic myeloid leukemia (CML) is facing the dilemma of tyrosine kinase inhibitors (TKIs) resistance and disease recurrence. The dysfunctional DNA damage repair mechanism plays an essential role not only in the initiation and progression of hematological malignancies but...

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Detalles Bibliográficos
Autores principales:	Zeng, Fanting, Peng, Yuhang, Qin, Yuefeng, Wang, Jianming, Jiang, Guoyun, Feng, Wenli, Yuan, Ying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9793686/ https://www.ncbi.nlm.nih.gov/pubmed/36575478 http://dx.doi.org/10.1186/s12964-022-01021-z

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