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COVID-19 patients’ clinical profile and outcome with respect to their vaccination status: A prospective observational multicentre cohort study during third wave in Western India
PURPOSE: To understand the benefits of COVID-19 vaccination (Covishield, Covaxin) on clinical features and outcome of COVID-19 during the third wave in India. MATERIALS AND METHODS: The primary study aim was to describe the clinical profile and outcome of COVID-19 regarding their vaccination and to...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Indian Association of Medical Microbiologists. Published by Elsevier B.V.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9793696/ https://www.ncbi.nlm.nih.gov/pubmed/36870745 http://dx.doi.org/10.1016/j.ijmmb.2022.12.004 |
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author | Patel, Atul K. Patel, Dhruv Shevkani, Manoj Shah, Aniket Madan, Surabhi Gohel, Swati Chhatwani, Chirag Doshi, Aakash Patel, Vipul Sukhwani, Kalpesh Kareliya, Hiten Shah, Vipul Savaj, Pratik Rana, Manish Patel, Ketan K. Bakshi, Harsh |
author_facet | Patel, Atul K. Patel, Dhruv Shevkani, Manoj Shah, Aniket Madan, Surabhi Gohel, Swati Chhatwani, Chirag Doshi, Aakash Patel, Vipul Sukhwani, Kalpesh Kareliya, Hiten Shah, Vipul Savaj, Pratik Rana, Manish Patel, Ketan K. Bakshi, Harsh |
author_sort | Patel, Atul K. |
collection | PubMed |
description | PURPOSE: To understand the benefits of COVID-19 vaccination (Covishield, Covaxin) on clinical features and outcome of COVID-19 during the third wave in India. MATERIALS AND METHODS: The primary study aim was to describe the clinical profile and outcome of COVID-19 regarding their vaccination and to identify risk factors for disease progression in vaccinated patients. This was a prospective observational multicentric study of COVID-19 attended by Infectious Disease physicians during January 15, 2022 to February 15, 2022. Adult patients with positive RT-PCR or rapid antigen test for COVID-19 were enrolled. Patient received treatment as per local institutional protocol. Chi square test for categorical and Mann Whitney test for continuous variables were applied for the analysis. Logistic regression was used to calculate adjusted odds ratios. RESULTS: A total of 788 patients were included in analysis out of 883 enrolled patients from 13 centers across Gujarat. By the end of two weeks’ follow up, 22 patients (2.8%) had expired. The Median age of subjects was 54 years, with a (55.8%) male. 90% of the subjects were vaccinated, majority (77%) of them had received 2 doses of vaccine with Covishield (659, 93%). Mortality among the non-vaccinated was significantly (11.4%) higher than vaccinated (1.8%). Logistic regression analysis showed numbers of comorbidities (p = 0.027), baseline higher WBC count (p = 0.02), higher NLR (p = 0.016), and Ct value (p = 0.046) were associated with mortality while vaccination was associated with survival (p = 0.001). The factors associated with mortality among vaccinated were age, comorbidities, baseline higher WBC, NLR, and CRP. CONCLUSIONS: Omicron variant was associated with mild symptoms. Clinical and laboratory risk factors for getting severe disease with Omicron variant were the same with previous SARS CoV-2 strain. Two doses of vaccine protect people against severe disease and death. Age, comorbidities, baseline leucocytosis, high NLR, elevated CRP are the risk factors for poor outcome in vaccinated patients. |
format | Online Article Text |
id | pubmed-9793696 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Indian Association of Medical Microbiologists. Published by Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97936962022-12-27 COVID-19 patients’ clinical profile and outcome with respect to their vaccination status: A prospective observational multicentre cohort study during third wave in Western India Patel, Atul K. Patel, Dhruv Shevkani, Manoj Shah, Aniket Madan, Surabhi Gohel, Swati Chhatwani, Chirag Doshi, Aakash Patel, Vipul Sukhwani, Kalpesh Kareliya, Hiten Shah, Vipul Savaj, Pratik Rana, Manish Patel, Ketan K. Bakshi, Harsh Indian J Med Microbiol Original Research Article PURPOSE: To understand the benefits of COVID-19 vaccination (Covishield, Covaxin) on clinical features and outcome of COVID-19 during the third wave in India. MATERIALS AND METHODS: The primary study aim was to describe the clinical profile and outcome of COVID-19 regarding their vaccination and to identify risk factors for disease progression in vaccinated patients. This was a prospective observational multicentric study of COVID-19 attended by Infectious Disease physicians during January 15, 2022 to February 15, 2022. Adult patients with positive RT-PCR or rapid antigen test for COVID-19 were enrolled. Patient received treatment as per local institutional protocol. Chi square test for categorical and Mann Whitney test for continuous variables were applied for the analysis. Logistic regression was used to calculate adjusted odds ratios. RESULTS: A total of 788 patients were included in analysis out of 883 enrolled patients from 13 centers across Gujarat. By the end of two weeks’ follow up, 22 patients (2.8%) had expired. The Median age of subjects was 54 years, with a (55.8%) male. 90% of the subjects were vaccinated, majority (77%) of them had received 2 doses of vaccine with Covishield (659, 93%). Mortality among the non-vaccinated was significantly (11.4%) higher than vaccinated (1.8%). Logistic regression analysis showed numbers of comorbidities (p = 0.027), baseline higher WBC count (p = 0.02), higher NLR (p = 0.016), and Ct value (p = 0.046) were associated with mortality while vaccination was associated with survival (p = 0.001). The factors associated with mortality among vaccinated were age, comorbidities, baseline higher WBC, NLR, and CRP. CONCLUSIONS: Omicron variant was associated with mild symptoms. Clinical and laboratory risk factors for getting severe disease with Omicron variant were the same with previous SARS CoV-2 strain. Two doses of vaccine protect people against severe disease and death. Age, comorbidities, baseline leucocytosis, high NLR, elevated CRP are the risk factors for poor outcome in vaccinated patients. Indian Association of Medical Microbiologists. Published by Elsevier B.V. 2023 2022-12-27 /pmc/articles/PMC9793696/ /pubmed/36870745 http://dx.doi.org/10.1016/j.ijmmb.2022.12.004 Text en © 2022 Indian Association of Medical Microbiologists. Published by Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Original Research Article Patel, Atul K. Patel, Dhruv Shevkani, Manoj Shah, Aniket Madan, Surabhi Gohel, Swati Chhatwani, Chirag Doshi, Aakash Patel, Vipul Sukhwani, Kalpesh Kareliya, Hiten Shah, Vipul Savaj, Pratik Rana, Manish Patel, Ketan K. Bakshi, Harsh COVID-19 patients’ clinical profile and outcome with respect to their vaccination status: A prospective observational multicentre cohort study during third wave in Western India |
title | COVID-19 patients’ clinical profile and outcome with respect to their vaccination status: A prospective observational multicentre cohort study during third wave in Western India |
title_full | COVID-19 patients’ clinical profile and outcome with respect to their vaccination status: A prospective observational multicentre cohort study during third wave in Western India |
title_fullStr | COVID-19 patients’ clinical profile and outcome with respect to their vaccination status: A prospective observational multicentre cohort study during third wave in Western India |
title_full_unstemmed | COVID-19 patients’ clinical profile and outcome with respect to their vaccination status: A prospective observational multicentre cohort study during third wave in Western India |
title_short | COVID-19 patients’ clinical profile and outcome with respect to their vaccination status: A prospective observational multicentre cohort study during third wave in Western India |
title_sort | covid-19 patients’ clinical profile and outcome with respect to their vaccination status: a prospective observational multicentre cohort study during third wave in western india |
topic | Original Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9793696/ https://www.ncbi.nlm.nih.gov/pubmed/36870745 http://dx.doi.org/10.1016/j.ijmmb.2022.12.004 |
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