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The connection between innervation and metabolic rearrangements in pancreatic cancer through serine
Pancreatic cancer is a kind of aggressive tumor famous for its lethality and intractability, and pancreatic ductal adenocarcinoma is the most common type. Patients with pancreatic cancer often suffer a rapid loss of weight and abdominal neuropathic pain in their early stages and then go through cach...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9793709/ https://www.ncbi.nlm.nih.gov/pubmed/36582785 http://dx.doi.org/10.3389/fonc.2022.992927 |
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author | Dong, Mengmeng Cao, Lidong Cui, Ranji Xie, Yingjun |
author_facet | Dong, Mengmeng Cao, Lidong Cui, Ranji Xie, Yingjun |
author_sort | Dong, Mengmeng |
collection | PubMed |
description | Pancreatic cancer is a kind of aggressive tumor famous for its lethality and intractability, and pancreatic ductal adenocarcinoma is the most common type. Patients with pancreatic cancer often suffer a rapid loss of weight and abdominal neuropathic pain in their early stages and then go through cachexia in the advanced stage. These features of patients are considered to be related to metabolic reprogramming of pancreatic cancer and abundant nerve innervation responsible for the pain. With increasing literature certifying the relationship between nerves and pancreatic ductal adenocarcinoma (PDAC), more evidence point out that innervation’s role is not limited to neuropathic pain but explore its anti/pro-tumor functions in PDAC, especially the neural–metabolic crosstalks. This review aims to unite pancreatic cancer’s innervation and metabolic rearrangements with terminated published articles. Hopefully, this article could explore the pathogenesis of PDAC and further promote promising detecting or therapeutic measurements for PDAC according to the lavish innervation in PDAC. |
format | Online Article Text |
id | pubmed-9793709 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97937092022-12-28 The connection between innervation and metabolic rearrangements in pancreatic cancer through serine Dong, Mengmeng Cao, Lidong Cui, Ranji Xie, Yingjun Front Oncol Oncology Pancreatic cancer is a kind of aggressive tumor famous for its lethality and intractability, and pancreatic ductal adenocarcinoma is the most common type. Patients with pancreatic cancer often suffer a rapid loss of weight and abdominal neuropathic pain in their early stages and then go through cachexia in the advanced stage. These features of patients are considered to be related to metabolic reprogramming of pancreatic cancer and abundant nerve innervation responsible for the pain. With increasing literature certifying the relationship between nerves and pancreatic ductal adenocarcinoma (PDAC), more evidence point out that innervation’s role is not limited to neuropathic pain but explore its anti/pro-tumor functions in PDAC, especially the neural–metabolic crosstalks. This review aims to unite pancreatic cancer’s innervation and metabolic rearrangements with terminated published articles. Hopefully, this article could explore the pathogenesis of PDAC and further promote promising detecting or therapeutic measurements for PDAC according to the lavish innervation in PDAC. Frontiers Media S.A. 2022-12-13 /pmc/articles/PMC9793709/ /pubmed/36582785 http://dx.doi.org/10.3389/fonc.2022.992927 Text en Copyright © 2022 Dong, Cao, Cui and Xie https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Dong, Mengmeng Cao, Lidong Cui, Ranji Xie, Yingjun The connection between innervation and metabolic rearrangements in pancreatic cancer through serine |
title | The connection between innervation and metabolic rearrangements in pancreatic cancer through serine |
title_full | The connection between innervation and metabolic rearrangements in pancreatic cancer through serine |
title_fullStr | The connection between innervation and metabolic rearrangements in pancreatic cancer through serine |
title_full_unstemmed | The connection between innervation and metabolic rearrangements in pancreatic cancer through serine |
title_short | The connection between innervation and metabolic rearrangements in pancreatic cancer through serine |
title_sort | connection between innervation and metabolic rearrangements in pancreatic cancer through serine |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9793709/ https://www.ncbi.nlm.nih.gov/pubmed/36582785 http://dx.doi.org/10.3389/fonc.2022.992927 |
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