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Anti-Epileptic Drug Target Perturbation and Intracranial Aneurysm Risk: Mendelian Randomization and Colocalization Study

In a genome-wide association study of intracranial aneurysms (IA), enrichment was found between genes associated with IA and genes encoding targets of effective anti-epileptic drugs. Our aim was to assess if this pleiotropy is driven by shared disease mechanisms that could potentially highlight a tr...

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Detalles Bibliográficos
Autores principales:	Bakker, Mark K., van Straten, Tijmen, Chong, Michael, Paré, Guillaume, Gill, Dipender, Ruigrok, Ynte M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2022
Materias:	Original Contributions
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9794136/ https://www.ncbi.nlm.nih.gov/pubmed/36300369 http://dx.doi.org/10.1161/STROKEAHA.122.040598

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