Progressive Cholestasis and Biliary Cirrhosis After Initiating Oral Semaglutide: Report From the Drug-Induced Liver Injury Network

Semaglutide has little hepatic metabolism and is deemed low risk for causing drug-induced liver injury (DILI). We present a case of DILI from the US DILI Network. The case involved a 51-year-old man with type 2 diabetes who presented with jaundice and acute-on-chronic kidney disease 6 months after s...

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Autores principales: Ma, Jiayi, Mathur, Karan, Muldoon, Jessica L., Ghabril, Marwan, Chalasani, Naga, Vuppalanchi, Raj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9794239/
https://www.ncbi.nlm.nih.gov/pubmed/36600793
http://dx.doi.org/10.14309/crj.0000000000000922
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author Ma, Jiayi
Mathur, Karan
Muldoon, Jessica L.
Ghabril, Marwan
Chalasani, Naga
Vuppalanchi, Raj
author_facet Ma, Jiayi
Mathur, Karan
Muldoon, Jessica L.
Ghabril, Marwan
Chalasani, Naga
Vuppalanchi, Raj
author_sort Ma, Jiayi
collection PubMed
description Semaglutide has little hepatic metabolism and is deemed low risk for causing drug-induced liver injury (DILI). We present a case of DILI from the US DILI Network. The case involved a 51-year-old man with type 2 diabetes who presented with jaundice and acute-on-chronic kidney disease 6 months after starting oral semaglutide. His liver injury progressed to biliary cirrhosis, accompanied by nephritis that led to end-stage renal disease. Extensive evaluations including liver and kidney biopsies revealed no alternative etiologies. Cholestatic gene sequencing revealed heterozygosity for ABCC2 and DHCR7. He eventually underwent combined liver and kidney transplantation.
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spelling pubmed-97942392023-01-03 Progressive Cholestasis and Biliary Cirrhosis After Initiating Oral Semaglutide: Report From the Drug-Induced Liver Injury Network Ma, Jiayi Mathur, Karan Muldoon, Jessica L. Ghabril, Marwan Chalasani, Naga Vuppalanchi, Raj ACG Case Rep J Case Report Semaglutide has little hepatic metabolism and is deemed low risk for causing drug-induced liver injury (DILI). We present a case of DILI from the US DILI Network. The case involved a 51-year-old man with type 2 diabetes who presented with jaundice and acute-on-chronic kidney disease 6 months after starting oral semaglutide. His liver injury progressed to biliary cirrhosis, accompanied by nephritis that led to end-stage renal disease. Extensive evaluations including liver and kidney biopsies revealed no alternative etiologies. Cholestatic gene sequencing revealed heterozygosity for ABCC2 and DHCR7. He eventually underwent combined liver and kidney transplantation. Wolters Kluwer 2022-12-26 /pmc/articles/PMC9794239/ /pubmed/36600793 http://dx.doi.org/10.14309/crj.0000000000000922 Text en © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Case Report
Ma, Jiayi
Mathur, Karan
Muldoon, Jessica L.
Ghabril, Marwan
Chalasani, Naga
Vuppalanchi, Raj
Progressive Cholestasis and Biliary Cirrhosis After Initiating Oral Semaglutide: Report From the Drug-Induced Liver Injury Network
title Progressive Cholestasis and Biliary Cirrhosis After Initiating Oral Semaglutide: Report From the Drug-Induced Liver Injury Network
title_full Progressive Cholestasis and Biliary Cirrhosis After Initiating Oral Semaglutide: Report From the Drug-Induced Liver Injury Network
title_fullStr Progressive Cholestasis and Biliary Cirrhosis After Initiating Oral Semaglutide: Report From the Drug-Induced Liver Injury Network
title_full_unstemmed Progressive Cholestasis and Biliary Cirrhosis After Initiating Oral Semaglutide: Report From the Drug-Induced Liver Injury Network
title_short Progressive Cholestasis and Biliary Cirrhosis After Initiating Oral Semaglutide: Report From the Drug-Induced Liver Injury Network
title_sort progressive cholestasis and biliary cirrhosis after initiating oral semaglutide: report from the drug-induced liver injury network
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9794239/
https://www.ncbi.nlm.nih.gov/pubmed/36600793
http://dx.doi.org/10.14309/crj.0000000000000922
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